Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL440487 | 0.86 | L3MBTL1 (0.36) | L3MBTL1PTGER4ALDH1A1KMT2ALMNA | |
| SCHEMBL14960654 | 0.86 | ALDH1A1 (0.37) | L3MBTL1PTGER4ALDH1A1KMT2ALMNA | |
| SCHEMBL9373962 | 0.85 | L3MBTL1 (0.42) | L3MBTL1PTGER4ALDH1A1KMT2ALMNA | |
| SCHEMBL28309097 | 0.84 | L3MBTL1 (0.36) | L3MBTL1PTGER4ALDH1A1KMT2ALMNA | |
| SCHEMBL406185 | 0.84 | L3MBTL1 (0.41) | L3MBTL1ALDH1A1KMT2ALMNAMEN1 | |
| SCHEMBL16344553 | 0.80 | L3MBTL1 (0.33) | L3MBTL1PTGER4ALDH1A1KMT2ALMNA | |
| SCHEMBL3401329 | 0.80 | KDM4E (0.40) | PTGER4ALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL437422 | 0.80 | PTGER4 (0.37) | PTGER4KMT2AMEN1 | |
| SCHEMBL15165797 | 0.80 | PTGER4 (0.35) | PTGER4KMT2AMEN1 | |
| SCHEMBL20550872 | 0.79 | PTGER4 (0.34) | PTGER4KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 105 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2560961-B1 | METHOD FOR PRODUCING 5-FLUOR-1-ALKYL-3-FLUOROALKYL-1H-PYRAZOL-4-CARBOXYLIC ACID AND CHLORIDES AND FLUORIDES | BAYER IP GMBH (DE) | 2016-11-16 | — | — | EP | claimed |
| US-20240368088-A1 | EP4 ANTAGONIST COMPOUND AS WELL AS SALT, POLYMORPH AND USE THEREOF | Wuhan Humanwell Innovative Drug Research and Development Center Limited Company (CN) | 2024-11-07 | — | — | US | disclosed |
| EP-4397654-A1 | EP4 ANTAGONIST COMPOUND AS WELL AS SALT, POLYMORPH, AND USE THEREOF | Wuhan Humanwell Innovative Drug Research and Development Center Limited Company (CN) | 2024-07-10 | — | — | EP | disclosed |
| US-20230125494-A1 | SYNTHESIS OF NOVEL EP4 ANTAGONIST AND USE IN CANCER AND INFLAMMATION | Wuhan Humanwell Innovative Drug Research and Development Center Limited Company (CN) | 2023-04-27 | — | — | US | disclosed |
| WO-2023030492-A1 | EP4 ANTAGONIST COMPOUND AS WELL AS SALT, POLYMORPH, AND USE THEREOF | 武汉人福创新药物研发中心有限公司 | 2023-03-09 | — | — | WO | disclosed |
| CN-115745892-A | EP4 antagonist compound and salt, polymorphism and application thereof | 武汉人福创新药物研发中心有限公司 | 2023-03-07 | — | — | CN | disclosed |
| EP-4116291-A1 | SYNTHESIS OF NOVEL EP4 ANTAGONIST AND USE IN CANCERS AND INFLAMMATIONS | Wuhan Humanwell Innovative Drug Research and Development Center Limited Company (CN) | 2023-01-11 | — | — | EP | disclosed |
| US-11230529-B2 | Method of preparing 3-fluoroalkyl-1 substituted pyrazol-4-carboxylic acid by air oxidation | ABA CHEMICALS (NANTONG) LIMITED (CN) | 2022-01-25 | — | — | US | disclosed |
| CN-113354585-A | Synthesis of novel EP4 antagonists and their use in cancer and inflammation | 湖北生物医药产业技术研究院有限公司 | 2021-09-07 | — | — | CN | disclosed |
| EP-3000809-B1 | FUNGICIDE PYRAZOLE CARBOXAMIDES DERIVATIVES | BAYER IP GMBH (DE) | 2018-10-31 | — | — | EP | disclosed |
| US-20120065164-A1 | FUNGICIDE PYRAZOLE CARBOXAMIDES DERIVATES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2012-03-15 | — | — | US | disclosed |
| WO-2011151383-A1 | O-CYCLOPROPYLCYCLOHEXYL-CARBOXANILIDES AND THEIR USE AS FUNGICIDES | BAYER CROPSCIENCE AG (DE) | 2011-12-08 | — | — | WO | disclosed |
| WO-2011151383-A1 | O-CYCLOPROPYLCYCLOHEXYL-CARBOXANILIDES AND THEIR USE AS FUNGICIDES | BAYER CROPSCIENCE AG (DE) | 2011-12-08 | — | — | WO | disclosed |
| WO-2011151370-A1 | N-[(HET)ARYLALKYL)] PYRAZOLE (THIO)CARBOXAMIDES AND THEIR HETEROSUBSTITUTED ANALOGUES | BAYER CROPSCIENCE AG (DE) | 2011-12-08 | — | — | WO | disclosed |
| WO-2011151369-A1 | N-[(HET)ARYLETHYL)] PYRAZOLE(THIO)CARBOXAMIDES AND THEIR HETEROSUBSTITUTED ANALOGUES | BAYER CROPSCIENCE AG (DE) | 2011-12-08 | — | — | WO | disclosed |
| WO-2010130767-A2 | FUNGICIDE PYRAZOLE CARBOXAMIDES DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2010-11-18 | — | — | WO | disclosed |
| EP-2251331-A1 | Fungicide pyrazole carboxamides derivatives | Bayer CropScience AG (DE) | 2010-11-17 | — | — | EP | disclosed |
| EP-0623113-B1 | PYRAZOLE CARBOXANILIDE FUNGICIDES | MONSANTO CO (US) | 1997-03-05 | — | — | EP | disclosed |
| US-5223526-A | For plants | MONSANTO COMPANY (US) | 1993-06-29 | — | — | US | disclosed |
| WO-1993011117-A1 | PYRAZOLE CARBOXANILIDE FUNGICIDES | MONSANTO COMPANY (US) | 1993-06-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11230529-B2 | Method of preparing 3-fluoroalkyl-1 substituted pyrazol-4-carboxylic acid by air oxidation | HAO2, AOX1, PPOX | L3MBTL1 4674/4885PTGER4 3858/4885ALDH1A1 85/4885 |
| US-20230125494-A1 | SYNTHESIS OF NOVEL EP4 ANTAGONIST AND USE IN CANCER AND INFLAMMATION | PTGER4, PTGER3, PTGER2 | L3MBTL1 4188/4885PTGER4 1/4885ALDH1A1 1807/4885 |
| US-20120065164-A1 | FUNGICIDE PYRAZOLE CARBOXAMIDES DERIVATES | CASP5, CTRL, CBR3 | L3MBTL1 1962/4885PTGER4 4061/4885ALDH1A1 4241/4885 |
| US-20240368088-A1 | EP4 ANTAGONIST COMPOUND AS WELL AS SALT, POLYMORPH AND USE THEREOF | PTGER4, PTGER1, PTGER2 | L3MBTL1 4714/4885PTGER4 1/4885ALDH1A1 1551/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.