Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 2/20 | 0.42 |
| ▸ | CCR5 | P51681 | 2/20 | 0.42 |
| ▸ | CCR8 | P51685 | 2/20 | 0.42 |
| ▸ | NOS3 | P29474 | 2/20 | 0.34 |
| ▸ | NOS2 | P35228 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.31 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL439739 | 0.87 | CCR1 (0.39) | CCR1CCR5CCR8KMT2AMAPT | |
| SCHEMBL440009 | 0.83 | HAVCR2 (0.38) | CCR1CCR5CCR8KMT2AMAPT | |
| SCHEMBL437847 | 0.79 | CCR1 (0.42) | CCR1CCR5CCR8NOS3NOS2 | |
| SCHEMBL441701 | 0.79 | ALDH1A1 (0.43) | LMNAPOLBKMT2AMAPTNPC1 | |
| SCHEMBL438308 | 0.75 | HAVCR2 (0.57) | CCR1CCR5CCR8POLBDHODH | |
| SCHEMBL436403 | 0.74 | POLB (0.38) | CCR1CCR5CCR8NOS3NOS2 | |
| SCHEMBL13539131 | 0.72 | CCR1 (0.78) | CCR1CCR5CCR8NOS3NOS2 | |
| SCHEMBL441974 | 0.72 | HAVCR2 (0.38) | CCR1CCR5CCR8KMT2AMAPT | |
| SCHEMBL442133 | 0.72 | BACE1 (0.41) | KMT2AMAPTALDH1A1HAVCR2MEN1 | |
| SCHEMBL435828 | 0.71 | ACHE (0.39) | CCR1CCR5CCR8NOS3NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120065166-A1 | Bone Modulators And Methods Therewith | ESPINA VIRGINIA (US) | 2012-03-15 | — | — | US | disclosed |