Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.97 |
| ▸ | GABRA1 | P14867 | 7/20 | 0.74 |
| ▸ | GABRB2 | P47870 | 6/20 | 0.74 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.74 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.74 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.74 |
| ▸ | LMNA | P02545 | 1/20 | 0.74 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.74 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.74 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.74 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.74 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.74 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Metomidate SCHEMBL491910 | 1.00 | MAPK1 (0.97) | MAPK1GABRA1GABRB2CYP11B1CYP11B2 | |
| Metomidate SCHEMBL1845324 | 0.99 | MAPK1 (1.00) | MAPK1GABRA1GABRB2CYP11B1CYP11B2 | |
| Metomidate SCHEMBL11733503 | 0.95 | MAPK1 (0.88) | MAPK1GABRA1GABRB2CYP11B1CYP11B2 | |
| SCHEMBL15125287 | 0.88 | MAPK1 (0.76) | MAPK1GABRA1GABRB2CYP11B1CYP11B2 | |
| SCHEMBL15125277 | 0.88 | MAPK1 (0.76) | MAPK1GABRA1GABRB2CYP11B1CYP11B2 | |
| SCHEMBL19062800 | 0.88 | MAPK1 (0.76) | MAPK1GABRA1GABRB2CYP11B1CYP11B2 | |
| SCHEMBL31406537 | 0.87 | MAPK1 (0.76) | MAPK1GABRA1GABRB2CYP11B1CYP11B2 | |
| SCHEMBL22004285 | 0.87 | MAPK1 (0.76) | MAPK1GABRA1GABRB2CYP11B1CYP11B2 | |
| SCHEMBL22259496 | 0.87 | MAPK1 (0.75) | MAPK1GABRA1GABRB2CYP11B1CYP11B2 | |
| SCHEMBL19063063 | 0.87 | MAPK1 (0.75) | MAPK1GABRA1GABRB2CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11434205-B2 | Substituted imidazole carboxylate derivatives and the use thereof | CHENGDU MFS PHARMA. CO., LTD. (CN) | 2022-09-06 | — | — | US | disclosed |
| EP-3184512-B1 | ANESTHETIC COMPOUNDS AND RELATED METHODS OF USE | MASSACHUSETTS GEN HOSPITAL (US) | 2020-12-23 | — | — | EP | disclosed |
| US-20180098968-A1 | ANESTHETIC COMPOUNDS AND RELATED METHODS OF USE | THE GENERAL HOSPITAL CORPORATION (US) | 2018-04-12 | — | — | US | disclosed |
| US-20180098968-A1 | ANESTHETIC COMPOUNDS AND RELATED METHODS OF USE | THE GENERAL HOSPITAL CORPORATION (US) | 2018-04-12 | — | — | US | disclosed |
| CN-107445898-A | N substituted imidazole carboxylic acid ester compounds and preparation method thereof and purposes in medicine | 四川海思科制药有限公司 | 2017-12-08 | — | — | CN | disclosed |
| US-9820971-B2 | Anesthetic compounds and related methods of use | THE GENERAL HOSPITAL CORPORATION (US) | 2017-11-21 | — | — | US | disclosed |
| US-9820971-B2 | Anesthetic compounds and related methods of use | THE GENERAL HOSPITAL CORPORATION (US) | 2017-11-21 | — | — | US | disclosed |
| US-20170273951-A1 | ANESTHETIC COMPOUNDS AND RELATED METHODS OF USE | THE GENERAL HOSPITAL CORPORATION (US) | 2017-09-28 | — | — | US | disclosed |
| US-20170273951-A1 | ANESTHETIC COMPOUNDS AND RELATED METHODS OF USE | THE GENERAL HOSPITAL CORPORATION (US) | 2017-09-28 | — | — | US | disclosed |
| EP-3184512-A1 | ANESTHETIC COMPOUNDS AND RELATED METHODS OF USE | The General Hospital Corporation (US) | 2017-06-28 | — | — | EP | disclosed |
| EP-2802325-B1 | ANESTHETIC COMPOUNDS AND RELATED METHODS OF USE | GEN HOSPITAL CORP (US) | 2016-11-30 | — | — | EP | disclosed |
| US-20150328189-A1 | ANESTHETIC COMPOUNDS AND RELATED METHODS OF USE | ANNOVATION BIOPHARMA, LLC. (US) | 2015-11-19 | — | — | US | disclosed |
| US-20150328189-A1 | ANESTHETIC COMPOUNDS AND RELATED METHODS OF USE | ANNOVATION BIOPHARMA, LLC. (US) | 2015-11-19 | — | — | US | disclosed |
| US-9156825-B2 | Anesthetic compounds and related methods of use | THE GENERAL HOSPITAL CORPORATION (US) | 2015-10-13 | — | — | US | disclosed |
| US-9156825-B2 | Anesthetic compounds and related methods of use | THE GENERAL HOSPITAL CORPORATION (US) | 2015-10-13 | — | — | US | disclosed |
| US-20150203476-A1 | ANESTHETIC COMPOUNDS AND RELATED METHODS OF USE | THE GENERAL HOSPITAL CORPORATION | 2015-07-23 | — | — | US | disclosed |
| US-20150203476-A1 | ANESTHETIC COMPOUNDS AND RELATED METHODS OF USE | THE GENERAL HOSPITAL CORPORATION | 2015-07-23 | — | — | US | disclosed |
| WO-2013106717-A1 | ANESTHETIC COMPOUNDS AND RELATED METHODS OF USE | THE GENERAL HOSPITAL CORPORATION (US) | 2013-07-18 | — | — | WO | disclosed |
| US-8071785-B2 | Synthesis and evaluation of 18F-labelled-alkyl-1-[(1R)-1-phenylethyl]-1H-imidazole-5-carboxylate as a tracer for the quantification of β-11-hydroxylase enzyme in the adrenal glands | GE HEALTHCARE LIMITED (GB) | 2011-12-06 | — | — | US | disclosed |
| US-20090297447-A1 | SYNTHESIS AND EVALUATION OF 18F-LABELLED-ALKYL-1-[(1R)-1-PHENYLETHYL]-1H-IMIDAZOLE-5-CARBOXYLATE AS A TRACER FOR THE QUANTIFICATION OF BETA-11-HYDROXYLASE ENZYME IN THE ADRENAL GLANDS | LANGSTROM BENGT | 2009-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150328189-A1 | ANESTHETIC COMPOUNDS AND RELATED METHODS OF USE | OPRM1, OPRK1, OPRL1 | MAPK1 4634/4885GABRA1 62/4885GABRB2 74/4885 |
| US-20090297447-A1 | SYNTHESIS AND EVALUATION OF 18F-LABELLED-ALKYL-1-[(1R)-1-PHENYLETHYL]-1H-IMIDAZOLE-5-CARBOXYLATE AS A TRACER FOR THE QUANTIFICATION OF BETA-11-HYDROXYLASE ENZYME IN THE ADRENAL GLANDS | HSD11B1, CYP21A2, CYP11B1 | MAPK1 3078/4885GABRA1 828/4885GABRB2 1953/4885 |
| US-20170273951-A1 | ANESTHETIC COMPOUNDS AND RELATED METHODS OF USE | OPRM1, OPRK1, OPRL1 | MAPK1 4634/4885GABRA1 62/4885GABRB2 74/4885 |
| US-20150203476-A1 | ANESTHETIC COMPOUNDS AND RELATED METHODS OF USE | OPRM1, OPRK1, OPRL1 | MAPK1 4634/4885GABRA1 62/4885GABRB2 74/4885 |
| US-11434205-B2 | Substituted imidazole carboxylate derivatives and the use thereof | SLC6A11, SLC6A13, SLC6A1 | MAPK1 2134/4885GABRA1 26/4885GABRB2 62/4885 |
| US-20180098968-A1 | ANESTHETIC COMPOUNDS AND RELATED METHODS OF USE | OPRM1, OPRK1, OPRL1 | MAPK1 4634/4885GABRA1 62/4885GABRB2 74/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.