Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEP1B | Q16820 | 6/20 | 0.36 |
| ▸ | SLC7A5 | Q01650 | 4/20 | 0.34 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | TMPRSS6 | Q8IU80 | 1/20 | 0.33 |
| ▸ | MEP1A | Q16819 | 2/20 | 0.32 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.32 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4370550 | 0.91 | HDAC6 (0.37) | BCL2L1MCL1ALDH1A1ST14F10 | |
| SCHEMBL4374490 | 0.82 | DPP4 (0.39) | MMP13 | |
| SCHEMBL1802359 | 0.79 | MMP2 (0.43) | ST14F10TMPRSS6MMP2MMP9 | |
| SCHEMBL4370554 | 0.75 | ST14 (0.39) | ST14F10MMP2MMP9MMP13 | |
| SCHEMBL1799336 | 0.75 | F2 (0.34) | ALDH1A1ST14F2PRSS1PRSS2 | |
| SCHEMBL4372182 | 0.73 | F10 (0.51) | ST14F10TMPRSS6F2 | |
| SCHEMBL1799060 | 0.70 | SLC9A3 (0.36) | ADAM10MMP2MMP9ADAM17 | |
| SCHEMBL4372334 | 0.70 | LTA4H (0.40) | ADAM10MMP2MMP9MMP13ADAM17 | |
| SCHEMBL4293042 | 0.70 | LTA4H (0.33) | ALDH1A1MMP2MMP9MMP13 | |
| SCHEMBL1797575 | 0.69 | MMP2 (0.43) | ST14TMPRSS6MMP2MMP9MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | disclosed |