Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 14/20 | 0.51 |
| ▸ | ST14 | Q9Y5Y6 | 10/20 | 0.51 |
| ▸ | TMPRSS6 | Q8IU80 | 6/20 | 0.51 |
| ▸ | F2 | P00734 | 7/20 | 0.47 |
| ▸ | PLG | P00747 | 9/20 | 0.46 |
| ▸ | PLAU | P00749 | 6/20 | 0.46 |
| ▸ | HPN | P05981 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1802359 | 0.92 | MMP2 (0.43) | F10ST14TMPRSS6F2PLG | |
| SCHEMBL4373478 | 0.90 | F2 (0.48) | F10ST14TMPRSS6F2PLG | |
| SCHEMBL1797575 | 0.84 | MMP2 (0.43) | ST14TMPRSS6F2 | |
| SCHEMBL14470899 | 0.78 | ADAM17 (0.50) | — | |
| SCHEMBL1799334 | 0.78 | ADAM17 (0.50) | — | |
| SCHEMBL1798952 | 0.75 | ADAMTS7 (0.45) | F10ST14TMPRSS6PLAUHPN | |
| SCHEMBL1798953 | 0.75 | ADAMTS7 (0.45) | F10ST14TMPRSS6PLAUHPN | |
| SCHEMBL1800796 | 0.75 | MMP1 (0.48) | — | |
| SCHEMBL1800798 | 0.75 | MMP1 (0.48) | — | |
| SCHEMBL4377255 | 0.73 | MEP1B (0.36) | F10ST14TMPRSS6F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | claimed |
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | disclosed |