Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | F10 | P00742 | 12/20 | 0.43 |
| ▸ | ST14 | Q9Y5Y6 | 9/20 | 0.43 |
| ▸ | TMPRSS6 | Q8IU80 | 6/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 6/20 | 0.39 |
| ▸ | PLG | P00747 | 6/20 | 0.39 |
| ▸ | PLAU | P00749 | 5/20 | 0.39 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.38 |
| ▸ | ADAMTS1 | Q9UHI8 | 1/20 | 0.38 |
| ▸ | ADAMTS7 | Q9UKP4 | 1/20 | 0.38 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | HPN | P05981 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4372182 | 0.92 | F10 (0.51) | F10ST14TMPRSS6F2PLG | |
| SCHEMBL1797575 | 0.90 | MMP2 (0.43) | MMP2MMP9ST14TMPRSS6CTSL | |
| SCHEMBL4373478 | 0.84 | F2 (0.48) | MMP2MMP9F10ST14TMPRSS6 | |
| SCHEMBL4377255 | 0.79 | MEP1B (0.36) | MMP2MMP9F10ST14TMPRSS6 | |
| SCHEMBL1800796 | 0.76 | MMP1 (0.48) | MMP2MMP9MMP1ADAM17MMP13 | |
| SCHEMBL1800798 | 0.76 | MMP1 (0.48) | MMP2MMP9MMP1ADAM17MMP13 | |
| SCHEMBL14470899 | 0.75 | ADAM17 (0.50) | MMP2MMP9ADAMTS4MMP1ADAM17 | |
| SCHEMBL1799334 | 0.75 | ADAM17 (0.50) | MMP2MMP9ADAMTS4MMP1ADAM17 | |
| SCHEMBL1798952 | 0.74 | ADAMTS7 (0.45) | MMP2MMP9F10ST14TMPRSS6 | |
| SCHEMBL1798953 | 0.74 | ADAMTS7 (0.45) | MMP2MMP9F10ST14TMPRSS6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | claimed |
| US-7498358-B2 | e.g. N1-hydroxy-N2-[(4-phenoxyphenyl)sulfonyl]-D-argininamide; metallopeptidase inhibitor; antiinflammation, anticarcinogenic, antidiabetic agent; angiogenesis inhibitor; atherosclerosis, stroke, ulcer, infertility, scleroderma, endometriosis, mesothelioma | EXELIXIS, INC. (US) | 2009-03-03 | — | — | US | claimed |
| US-20050227973-A1 | Human adam-10 inhibitors | EXELIXIS, INC. | 2005-10-13 | — | — | US | claimed |
| US-7951972-B2 | Human adam-10 inhibitors | EXELIXIS, INC. (US) | 2011-05-31 | — | — | US | disclosed |
| US-20090143386-A1 | Human adam-10 inhibitors | EXELIXIS, INC. | 2009-06-04 | — | — | US | disclosed |
| US-7498358-B2 | e.g. N1-hydroxy-N2-[(4-phenoxyphenyl)sulfonyl]-D-argininamide; metallopeptidase inhibitor; antiinflammation, anticarcinogenic, antidiabetic agent; angiogenesis inhibitor; atherosclerosis, stroke, ulcer, infertility, scleroderma, endometriosis, mesothelioma | EXELIXIS, INC. (US) | 2009-03-03 | — | — | US | disclosed |
| US-20050227973-A1 | Human adam-10 inhibitors | EXELIXIS, INC. | 2005-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050227973-A1 | Human adam-10 inhibitors | ADAM10, ADAM12, ADAM9 | MMP2 133/4885MMP9 35/4885F10 57/4885 |
| US-20090143386-A1 | Human adam-10 inhibitors | ADAM10, ADAM12, CASP10 | MMP2 203/4885MMP9 82/4885F10 27/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.