Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | G6PD | P11413 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | TPI1 | P60174 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | LIG1 | P18858 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | LIG3 | P49916 | 1/20 | 0.43 |
| ▸ | LIG4 | P49917 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4379829 | 1.00 | ALDH1A1 (0.47) | ALDH1A1MAPTMEN1HPGDKMT2A | |
| SCHEMBL9766429 | 0.83 | KMT2A (0.46) | ALDH1A1MAPTMEN1HPGDKMT2A | |
| SCHEMBL9766431 | 0.83 | KMT2A (0.46) | ALDH1A1MAPTMEN1HPGDKMT2A | |
| SCHEMBL4407466 | 0.77 | G6PD (0.57) | ALDH1A1HPGDKMT2AG6PDCDK1 | |
| SCHEMBL7436514 | 0.77 | G6PD (0.57) | ALDH1A1HPGDKMT2AG6PDCDK1 | |
| SCHEMBL24127400 | 0.74 | ALDH1A1 (0.43) | ALDH1A1MAPTMEN1HPGDKMT2A | |
| SCHEMBL4193697 | 0.73 | CASP6 (0.66) | ALDH1A1MAPTMEN1HPGDKMT2A | |
| SCHEMBL24127401 | 0.72 | CA12 (0.47) | ALDH1A1MAPTMEN1HPGDKMT2A | |
| SCHEMBL2950116 | 0.71 | MAPT (0.65) | ALDH1A1MAPTMEN1HPGDKMT2A | |
| SCHEMBL2950117 | 0.71 | MAPT (0.65) | ALDH1A1MAPTMEN1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8871751-B2 | Compositions and methods relating to nuclear hormone and steroid hormone receptors including inhibitors of estrogen receptor alpha-mediated gene expression and inhibition of breast cancer | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2014-10-28 | — | — | US | disclosed |
| US-20090291972-A1 | Compositions and Methods Relating to Nuclear Hormone and Steroid Hormone Receptors Including Inhibitors of Estrogen Receptor Alpha-mediated Gene Expression and Inhibition of Breast Cancer | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS | 2009-11-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090291972-A1 | Compositions and Methods Relating to Nuclear Hormone and Steroid Hormone Receptors Including Inhibitors of Estrogen Receptor Alpha-mediated Gene Expression and Inhibition of Breast Cancer | PGR, ESR1, CYP19A1 | ALDH1A1 803/4885MAPT 4478/4885MEN1 3667/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.