Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT3A | P56704 | 2/20 | 0.37 |
| ▸ | MMP1 | P03956 | 3/20 | 0.36 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.36 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.36 |
| ▸ | ADAMTS1 | Q9UHI8 | 1/20 | 0.36 |
| ▸ | ADAMTS7 | Q9UKP4 | 1/20 | 0.36 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1800984 | 0.87 | ADAM17 (0.40) | MMP1ADAM17ADAMTS4ADAMTS1ADAMTS7 | |
| SCHEMBL1798434 | 0.85 | ADAM17 (0.43) | MMP1ADAM17ADAMTS4ADAMTS1ADAMTS7 | |
| SCHEMBL1802616 | 0.85 | SIRT5 (0.41) | MMP1ADAM17ADAMTS4ADAMTS1ADAMTS7 | |
| SCHEMBL11989266 | 0.85 | SIRT5 (0.41) | MMP1ADAM17ADAMTS4ADAMTS1ADAMTS7 | |
| SCHEMBL1798298 | 0.84 | ADAM17 (0.41) | MMP1ADAM17ADAMTS4ADAMTS1ADAMTS7 | |
| SCHEMBL1797052 | 0.83 | F2 (0.37) | WNT3AMAP4K4ALDH1A1KDM4ECNR2 | |
| SCHEMBL4381231 | 0.81 | BMP1 (0.43) | MMP1ADAM17KMT2AMMP2MMP9 | |
| SCHEMBL4372679 | 0.76 | MMP2 (0.47) | MMP1ADAM17ADAMTS4ADAMTS1ADAMTS7 | |
| SCHEMBL4372697 | 0.75 | MMP2 (0.46) | MMP1ADAM17ADAMTS4ADAMTS1ADAMTS7 | |
| SCHEMBL7174227 | 0.74 | CA2 (0.34) | WNT3AMMP1ADAM17ADAMTS4ADAMTS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | disclosed |