Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 3/20 | 0.36 |
| ▸ | CTSK | P43235 | 2/20 | 0.36 |
| ▸ | HTR7 | P34969 | 2/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.35 |
| ▸ | NOS3 | P29474 | 8/20 | 0.34 |
| ▸ | NOS1 | P29475 | 8/20 | 0.34 |
| ▸ | NOS2 | P35228 | 6/20 | 0.34 |
| ▸ | HTR1B | P28222 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4384328 | 0.90 | PTPN1 (0.36) | CTSSCTSKPTPN1DRD2 | |
| SCHEMBL4381198 | 0.89 | PTPN1 (0.38) | PTPN1DRD2KDM4EALDH1A1 | |
| SCHEMBL4384579 | 0.88 | PTPN1 (0.37) | CTSSCTSKPTPN1 | |
| SCHEMBL4380448 | 0.87 | LTA4H (0.43) | HTR7NOS3NOS1NOS2DRD2 | |
| SCHEMBL4373757 | 0.85 | HTR2A (0.38) | PTPN1DRD2KDM4E | |
| SCHEMBL4378503 | 0.85 | PTPN1 (0.48) | PTPN1 | |
| SCHEMBL3742273 | 0.83 | PTPN1 (0.36) | PTPN1 | |
| SCHEMBL4379622 | 0.82 | PTPN1 (0.37) | HTR7PTPN1 | |
| SCHEMBL4389955 | 0.81 | PTPN1 (0.51) | PTPN1DRD2 | |
| SCHEMBL3739976 | 0.81 | PTPN1 (0.32) | PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910359-B1 | PYRIDO [2 , 3-D]PYRIMIDINE-2 , 4-DIAMINE COMPOUNDS AS PTPlB INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-11-18 | — | — | EP | claimed |