Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 2/20 | 0.38 |
| ▸ | AR | P10275 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | MIF | P14174 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 4/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | LTA4H | P09960 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4384328 | 0.91 | PTPN1 (0.36) | PTPN1HTR2AHTR2CHTR2BDRD2 | |
| SCHEMBL4384579 | 0.89 | PTPN1 (0.37) | PTPN1HTR2AHTR2CHTR2B | |
| SCHEMBL4380448 | 0.89 | LTA4H (0.43) | HTR2AHTR2CHTR2BDRD2ALDH1A1 | |
| SCHEMBL4381287 | 0.89 | CTSS (0.36) | PTPN1DRD2KDM4EALDH1A1 | |
| SCHEMBL4378503 | 0.88 | PTPN1 (0.48) | PTPN1ARHTR2AHTR2CHTR2B | |
| SCHEMBL4373757 | 0.87 | HTR2A (0.38) | PTPN1HTR2AHTR2CHTR2BDRD2 | |
| SCHEMBL3742273 | 0.85 | PTPN1 (0.36) | PTPN1HTR2AHTR2CHTR2B | |
| SCHEMBL4379622 | 0.83 | PTPN1 (0.37) | PTPN1HTR2AHTR2CHTR2B | |
| SCHEMBL4524489 | 0.83 | AR (0.40) | ARHTR2AHTR2CHTR2BDRD2 | |
| SCHEMBL4389955 | 0.83 | PTPN1 (0.51) | PTPN1HTR2AHTR2CHTR2BDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910359-B1 | PYRIDO [2 , 3-D]PYRIMIDINE-2 , 4-DIAMINE COMPOUNDS AS PTPlB INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-11-18 | — | — | EP | claimed |