Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 13/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4385766 | 0.89 | RAB9A (0.51) | HSD11B1RAB9AHTTALDH1A1MEN1 | |
| SCHEMBL4386485 | 0.88 | HSD11B1 (0.51) | HSD11B1RAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL4386498 | 0.86 | ALDH1A1 (0.54) | HSD11B1RAB9AHTTALDH1A1MEN1 | |
| SCHEMBL4377829 | 0.84 | ALDH1A1 (0.45) | HSD11B1RAB9AHTTALDH1A1MEN1 | |
| SCHEMBL4952879 | 0.83 | MEN1 (0.47) | ALDH1A1MEN1KMT2AL3MBTL1CNR1 | |
| SCHEMBL4391863 | 0.83 | MAPT (0.40) | RAB9AALDH1A1MEN1KMT2ACNR1 | |
| SCHEMBL4391283 | 0.83 | CYP2C9 (0.39) | ALDH1A1MEN1KMT2AL3MBTL1CNR1 | |
| SCHEMBL4383616 | 0.81 | MEN1 (0.47) | ALDH1A1MEN1KMT2AL3MBTL1CNR1 | |
| SCHEMBL3376845 | 0.79 | HCRTR2 (0.46) | ALDH1A1MEN1KMT2A | |
| SCHEMBL4387186 | 0.79 | L3MBTL1 (0.56) | MEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1939187-A1 | Substituted heteroaryl pyridopyrimidone derivatives | Sanofi-Aventis (FR) | 2008-07-02 | — | — | EP | claimed |
| US-8198287-B2 | Substituted heteroaryl pyridopyrimidone derivatives | SANOFI-AVENTIS (FR) | 2012-06-12 | — | — | US | disclosed |
| EP-1939187-A1 | Substituted heteroaryl pyridopyrimidone derivatives | Sanofi-Aventis (FR) | 2008-07-02 | — | — | EP | disclosed |