SCHEMBL4386989

SCHEMBL4386989

NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O

nearest known ligand 0.52

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
PTPN2 P17706 1/20 0.52
PTPN1 P18031 1/20 0.52
ACE P12821 3/20 0.51
HPGDS O60760 3/20 0.48
CA12 O43570 1/20 0.47
CA1 P00915 1/20 0.47
CA9 Q16790 1/20 0.47
CHRND Q07001 6/20 0.47
CHRNA1 P02708 2/20 0.47
CHRNG P07510 2/20 0.47
CHRNB1 P11230 2/20 0.47
GRIA1 P42261 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5594950 1.00 PTPN2 (0.52) PTPN2PTPN1ACEHPGDSCA12
Hydrochloric Acid SCHEMBL12469709 0.98 PTPN2 (0.51) PTPN2PTPN1ACEHPGDSCA12
SCHEMBL26605060 0.90 OPRD1 (0.48) PTPN2PTPN1ACEHPGDSCHRND
SCHEMBL26605068 0.90 OPRD1 (0.48) PTPN2PTPN1ACEHPGDSCHRND
SCHEMBL30316218 0.89 PTPN1 (0.58) PTPN2PTPN1ACECHRNDCHRNA1
SCHEMBL6757142 0.87 PTPN2 (0.52) PTPN2PTPN1ACEHPGDSCA12
SCHEMBL7110134 0.87 ACE (0.60) ACECA1CHRNDCHRNA1CHRNG
SCHEMBL3459805 0.87 ACE (0.60) ACECA1CHRNDCHRNA1CHRNG
SCHEMBL7110125 0.87 ACE (0.60) ACECA1CHRNDCHRNA1CHRNG
SCHEMBL479126 0.87 ACE (0.60) ACECA1CHRNDCHRNA1CHRNG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260108619-A1 CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS HANGZHOU DAC BIOTECH CO., LTD. (CN) 2026-04-23 US claimed
US-11851468-B2 Treatment of neurological diseases UNIVERSITY OF LANCASTER (GB) 2023-12-26 US claimed
US-20230071112-A1 CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS HANGZHOU DAC BIOTECH CO., LTD. (CN) 2023-03-09 US claimed
US-20220313836-A1 CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS HANGZHOU DAC BIOTECH CO., LTD. (CN) 2022-10-06 US claimed
EP-4018997-A1 N-LIPOIC -AMINO ACID OR PEPTIDE, DERIVATIVES AND THEIR USES NeoStrata Company, Inc. (US) 2022-06-29 EP claimed
US-5298491-A Derivatives of endogenous mediators, their salts, method of preparation, applications and compositions in which they are present IMMUNOTECH (FR) 1994-03-29 US claimed
US-20260063648-A1 Method for the prediction of a risk or severity of side effects in a cancer patient that is to be treated or has been treated with immune effector cell therapy (IECT) PAM THERAGNOSTICS GMBH (DE) 2026-03-05 US disclosed
US-12528827-B2 Tricyclic heteroaryl-substituted quinoline and azaquinoline compounds as PAR4 inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2026-01-20 US disclosed
US-12508321-B2 Conjugation linkers, cell binding molecule-drug conjugates containing the linkers, methods of making and uses such conjugates with the linkers HANGZHOU DAC BIOTECH CO., LTD. (CN) 2025-12-30 US disclosed
US-12435056-B2 N-lipoic-amino acid or peptide, derivatives and their uses NEOSTRATA COMPANY, INC. (US) 2025-10-07 US disclosed
US-12364767-B2 Conjugation linkers, cell binding molecule-drug conjugates containing the linkers, methods of making and uses such conjugates with the linkers HANGZHOU DAC BIOTECH CO., LTD. (CN) 2025-07-22 US disclosed
US-12303571-B2 Specific conjugation linkers, specific immunoconjugates thereof, methods of making and uses such conjugates thereof HANGZHOU DAC BIOTECH CO., LTD. (CN) 2025-05-20 US disclosed
US-20250154219-A1 PEPTIDE ANALOGS ADEPTHERA LLC 2025-05-15 US disclosed
WO-2001087287-A2 USE OF PYRAZOLE DERIVATIVES FOR TREATING INFERTILITY APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) 2001-11-22 WO disclosed
EP-1104438-A2 NOVEL ANTI-DIABETIC PEPTIDES AMYLIN PHARMACEUTICALS, INC. (US) 2001-06-06 EP disclosed
WO-2000011029-A2 NOVEL ANTI-DIABETIC PEPTIDES AMYLIN PHARMACEUTICALS, INC. (US) 2000-03-02 WO disclosed
EP-0457701-B1 Derivatives of endogenous mediators, their salts, process for preparation, application and compositions containing them IMMUNOTECH SA (FR) 1995-02-22 EP disclosed
US-5298491-A Derivatives of endogenous mediators, their salts, method of preparation, applications and compositions in which they are present IMMUNOTECH (FR) 1994-03-29 US disclosed
EP-0457701-A1 Derivatives of endogenous mediators, their salts, process for preparation, application and compositions containing them IMMUNOTECH S.A. (FR) 1991-11-21 EP disclosed
US-4818683-A Immunoassay for monoamines IMMUNOTECH (FR) 1989-04-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12508321-B2 Conjugation linkers, cell binding molecule-drug conjugates containing the linkers, methods of making and uses such conjugates with the linkers CD4, CD2, B2M PTPN2 2675/4885PTPN1 2381/4885ACE 3561/4885
US-12435056-B2 N-lipoic-amino acid or peptide, derivatives and their uses CUTA, ALAD, NACA PTPN2 1241/4885PTPN1 1329/4885ACE 1877/4885
US-20250154219-A1 PEPTIDE ANALOGS RAMP1, RAMP2, RAMP3 PTPN2 1816/4885PTPN1 1782/4885ACE 2255/4885
US-20220313836-A1 CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS CD2BP2, DCLRE1A, EPCAM PTPN2 3853/4885PTPN1 3907/4885ACE 4146/4885
US-12303571-B2 Specific conjugation linkers, specific immunoconjugates thereof, methods of making and uses such conjugates thereof SLC25A1, GCDH, FH PTPN2 3615/4885PTPN1 3946/4885ACE 3845/4885
US-20260063648-A1 Method for the prediction of a risk or severity of side effects in a cancer patient that is to be treated or has been treated with immune effector cell therapy (IECT) KLKB1, EPCAM, ECE1 PTPN2 1650/4885PTPN1 1621/4885ACE 1206/4885
US-20260108619-A1 CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS DCLRE1A, CCR3, CCR8 PTPN2 2272/4885PTPN1 1785/4885ACE 4519/4885
US-12364767-B2 Conjugation linkers, cell binding molecule-drug conjugates containing the linkers, methods of making and uses such conjugates with the linkers CD2BP2, DCLRE1A, EPCAM PTPN2 3853/4885PTPN1 3907/4885ACE 4146/4885
US-12528827-B2 Tricyclic heteroaryl-substituted quinoline and azaquinoline compounds as PAR4 inhibitors F2RL3, F2R, PF4 PTPN2 805/4885PTPN1 561/4885ACE 1998/4885
US-20230071112-A1 CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS CD2BP2, DCLRE1A, EPCAM PTPN2 3807/4885PTPN1 3811/4885ACE 4174/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.