Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.54 |
| ▸ | CES1 | P23141 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4389147 | 1.00 | CES2 (0.54) | CES2CES1HTTSMN1; SMN2NPSR1 | |
| SCHEMBL345282 | 0.94 | HDAC3 (0.51) | CES2CES1MEN1KMT2AHDAC3 | |
| SCHEMBL1070286 | 0.89 | MEN1 (0.53) | SMN1; SMN2NPSR1MEN1KMT2ANPC1 | |
| SCHEMBL13264797 | 0.88 | MAPT (0.52) | CES2CES1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL8999208 | 0.86 | NPC1 (0.50) | CES2CES1HTTSMN1; SMN2NPSR1 | |
| SCHEMBL8999201 | 0.86 | NPC1 (0.50) | CES2CES1HTTSMN1; SMN2NPSR1 | |
| SCHEMBL11891940 | 0.86 | ALDH1A1 (0.54) | HTTSMN1; SMN2NPSR1MEN1KMT2A | |
| SCHEMBL11296722 | 0.86 | ALDH1A1 (0.54) | HTTSMN1; SMN2NPSR1MEN1KMT2A | |
| SCHEMBL11296725 | 0.86 | ALDH1A1 (0.54) | HTTSMN1; SMN2NPSR1MEN1KMT2A | |
| SCHEMBL5500811 | 0.85 | L3MBTL1 (0.50) | HTTSMN1; SMN2MEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1626046-B1 | Photochromic oxazine compounds and methods for their manufacture | ESSILOR INT (FR) | 2014-11-19 | — | — | EP | disclosed |
| EP-1458695-B1 | Method for the manufacture of photochromic oxazine compounds and compounds obtainable therefrom | ESSILOR INT (FR) | 2012-10-03 | — | — | EP | disclosed |
| EP-1446390-B1 | PHOTOCHROMIC OXAZINE COMPOUNDS AND METHODS FOR THEIR MANUFACTURE | ESSILOR INT (FR) | 2009-12-02 | — | — | EP | disclosed |
| EP-1626046-A1 | Photochromic oxazine compounds and methods for their manufacture | Johson & Johnson Vision Care Inc. (US) | 2006-02-15 | — | — | EP | disclosed |
| EP-1458695-A1 | PHOTOCHROMIC OXAZINE COMPOUNDS AND METHODS FOR THEIR MANUFACTURE | ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE) (FR) | 2004-09-22 | — | — | EP | disclosed |
| EP-1446390-A2 | PHOTOCHROMIC OXAZINE COMPOUNDS AND METHODS FOR THEIR MANUFACTURE | ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE) (FR) | 2004-08-18 | — | — | EP | disclosed |
| US-6720420-B2 | AROMATIC, HETEROAROMATIC, OR ALIPHATIC SUBSTITUENTS AT THE 2 POSITION OF THE OXAZINE MOIETY; REACTING 3,3-DISUBSTITUTED ACRYLIC ACID, AZIDE SOURCE, QUINONE WITH CATALYTIC TRIPHENYLARSENIC OXIDE AND DBU; QUICKLY FADING GRAY COLOR | JOHNSON & JOHNSON VISION CARE, INC. | 2004-04-13 | — | — | US | disclosed |
| WO-2003057679-A9 | PHOTOCHROMIC OXAZINE COMPOUNDS AND METHODS FOR THEIR MANUFACTURE | JOHNSON & JOHNSON VISION CARE (US) | 2004-02-26 | — | — | WO | disclosed |
| US-6686466-B2 | HEATING AN ISOCYANATE DERIVATIVE WITH A SYMMETRIC QUINONE IN PRESENCE OF TRIPHENYLARSEN OXIDE CATALYST TO FORM 2,2-DIPHENYL-PHENANTHRO (9,10)-2H-(1,4)-OXAZINE DERIVATIVES | JOHNSON & JOHNSON VISION CARE, INC. | 2004-02-03 | — | — | US | disclosed |
| US-20030149032-A1 | Photochromic oxazine compounds and methods for their manufacture | ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE) (FR) | 2003-08-07 | — | — | US | disclosed |
| WO-2003057679-A1 | PHOTOCHROMIC OXAZINE COMPOUNDS AND METHODS FOR THEIR MANUFACTURE | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2003-07-17 | — | — | WO | disclosed |
| US-20030125552-A1 | Photochromic oxazine compounds and methods for their manufacture | ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE) (FR) | 2003-07-03 | — | — | US | disclosed |
| WO-2003042195-A2 | PHOTOCHROMIC OXAZINE COMPOUNDS AND METHODS FOR THEIR MANUFACTURE | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2003-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030149032-A1 | Photochromic oxazine compounds and methods for their manufacture | PPOX, TYR, DHPS | CES2 1826/4885CES1 3890/4885HTT 464/4885 |
| US-20030125552-A1 | Photochromic oxazine compounds and methods for their manufacture | PPOX, DHPS, ALDH1A2 | CES2 1101/4885CES1 4060/4885HTT 643/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.