Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | MLYCD | O95822 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7988780 | 0.83 | HDAC6 (0.58) | HDAC6HCRTR1HCRTR2LMNAALDH1A1 | |
| SCHEMBL4372942 | 0.82 | HDAC6 (0.51) | HDAC6CYP3A4HCRTR1HCRTR2LMNA | |
| SCHEMBL4384318 | 0.81 | HDAC6 (0.48) | HDAC6CYP3A4HCRTR1HCRTR2LMNA | |
| SCHEMBL6780327 | 0.80 | CTSS (0.61) | HDAC6HCRTR1HCRTR2CTSS | |
| SCHEMBL1447540 | 0.80 | P2RX7 (0.58) | HDAC6HCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL29646334 | 0.80 | P2RX7 (0.58) | HDAC6HCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL21209660 | 0.80 | NAPRT (0.56) | MAPK8PDE4AKCNH2RIPK1PDE4B | |
| SCHEMBL844529 | 0.80 | KDM4E (0.51) | HDAC6L3MBTL1HCRTR1HCRTR2LMNA | |
| SCHEMBL268777 | 0.78 | P2RX7 (0.65) | MAPK8PDE4AKCNH2L3MBTL1RIPK1 | |
| SCHEMBL165047 | 0.78 | MAPK8 (0.48) | MAPK8PDE4AKCNH2L3MBTL1RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022140390-A1 | INHIBITORS OF PEPTIDYLARGININE DEIMINASES | GILEAD SCIENCES, INC. (US) | 2022-06-30 | — | — | WO | disclosed |
| US-7629348-B2 | Heterocyclic amide and imine derivatives, processes for their preparation, compositions comprising them and their use as pesticides | MERIAL LIMITED (US) | 2009-12-08 | — | — | US | disclosed |
| US-20080139627-A1 | Heterocyclic amide and imine derivatives, processes for their preparation, compositions comprising them and their use as pesticides | BECKMANN MARION | 2008-06-12 | — | — | US | disclosed |
| US-20080097099-A1 | Heterocyclic amide and imine derivatives, processes for their preparation, compositions comprising them and their use as pesticides | BECKMANN MARION | 2008-04-24 | — | — | US | disclosed |
| US-7235571-B2 | Heterocyclic amide and imine derivatives, processes for their preparation, compositions comprising them and their use as pesticides | MERIAL LIMITED (US) | 2007-06-26 | — | — | US | disclosed |
| US-20040192712-A1 | Heterocyclic amide and imine derivatives, processes for their preparation, compositions comprising them and their use as pesticides | MERIAL LIMITED | 2004-09-30 | — | — | US | disclosed |
| US-20030119852-A1 | Heterocyclic amide and imine derivatives, processes for their preparation, compositions, comprising them and their use as pesticides | BAYER CROPSCIENCE GMBH (GE) | 2003-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080139627-A1 | Heterocyclic amide and imine derivatives, processes for their preparation, compositions comprising them and their use as pesticides | ACHE, DDT, PIR | HDAC6 719/4885NPSR1 2312/4885MAPK8 2282/4885 |
| US-20040192712-A1 | Heterocyclic amide and imine derivatives, processes for their preparation, compositions comprising them and their use as pesticides | ACHE, DDT, PIR | HDAC6 913/4885NPSR1 2100/4885MAPK8 2464/4885 |
| US-20030119852-A1 | Heterocyclic amide and imine derivatives, processes for their preparation, compositions, comprising them and their use as pesticides | ACHE, DDT, PIR | HDAC6 1204/4885NPSR1 2289/4885MAPK8 2917/4885 |
| US-20080097099-A1 | Heterocyclic amide and imine derivatives, processes for their preparation, compositions comprising them and their use as pesticides | ACHE, DDT, PIR | HDAC6 904/4885NPSR1 2417/4885MAPK8 1938/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.