Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.32 |
| ▸ | CCR5 | P51681 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4406699 | 0.94 | KMT2A (0.34) | HTR1ASLC6A4MCHR1KMT2AACHE | |
| SCHEMBL4396316 | 0.94 | KMT2A (0.34) | HTR1ASLC6A4MCHR1KMT2AACHE | |
| SCHEMBL4399335 | 0.91 | KMT2A (0.32) | HTR1ASLC6A4MCHR1KMT2AACHE | |
| SCHEMBL4398622 | 0.91 | KMT2A (0.32) | HTR1ASLC6A4MCHR1KMT2AACHE | |
| SCHEMBL4409082 | 0.90 | SRD5A2 (0.36) | MCHR1PDE3BPDE3AKMT2AMEN1 | |
| SCHEMBL914713 | 0.89 | KMT2A (0.41) | HTR1ASLC6A4TLR9TLR8TLR7 | |
| SCHEMBL4403441 | 0.87 | HTR1A (0.40) | HTR1ASLC6A4TLR9TLR8TLR7 | |
| SCHEMBL4403759 | 0.86 | HTR1A (0.37) | HTR1ASLC6A4TLR9TLR8TLR7 | |
| SCHEMBL4401792 | 0.85 | DRD2 (0.35) | HTR1ASLC6A4TLR9TLR8TLR7 | |
| SCHEMBL4396432 | 0.85 | HTR1A (0.36) | HTR1ASLC6A4TLR9TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720859-B1 | CHEMOKINE RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 2009-12-23 | — | — | EP | claimed |