Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 9/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4405878 | 0.93 | LMNA (0.40) | HTR1ASLC6A4LMNAPARP1ADRB3 | |
| SCHEMBL4403759 | 0.91 | HTR1A (0.37) | HTR1ASLC6A4LMNAPARP1ADRB3 | |
| SCHEMBL4396585 | 0.91 | LMNA (0.40) | HTR1ASLC6A4LMNAPARP1ADRB3 | |
| SCHEMBL4396432 | 0.90 | HTR1A (0.36) | HTR1ASLC6A4LMNAPARP1ADRB3 | |
| SCHEMBL4409085 | 0.88 | LMNA (0.40) | HTR1ASLC6A4LMNAPARP1ADRB3 | |
| SCHEMBL914856 | 0.87 | KMT2A (0.43) | HTR1ASLC6A4PARP1TLR9TLR8 | |
| SCHEMBL4411341 | 0.87 | HTR1A (0.34) | HTR1ASLC6A4PARP1TLR9TLR8 | |
| SCHEMBL4401792 | 0.85 | DRD2 (0.35) | HTR1ASLC6A4TLR9TLR8TLR7 | |
| SCHEMBL4551166 | 0.84 | LMNA (0.42) | HTR1ALMNAPARP1ADRB3 | |
| SCHEMBL4405571 | 0.84 | KDM4E (0.39) | HTR1ALMNAPARP1ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720859-B1 | CHEMOKINE RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 2009-12-23 | — | — | EP | claimed |