Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NOS2 | P35228 | 3/20 | 0.41 |
| ▸ | NOS1 | P29475 | 2/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 2/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL436991 | 0.89 | NOS3 (0.41) | POLBNOS2NOS1NOS3MCHR1 | |
| SCHEMBL437233 | 0.78 | NR4A2 (0.51) | POLBKDM4EMAPTLMNAHTT | |
| SCHEMBL439885 | 0.77 | NOS3 (0.41) | NOS2NOS1NOS3MCHR1BACE1 | |
| SCHEMBL441438 | 0.76 | MAPT (0.43) | KDM4ENOS2NOS1NOS3MCHR1 | |
| SCHEMBL438225 | 0.75 | MCHR1 (0.42) | POLBNOS2NOS1NOS3MCHR1 | |
| SCHEMBL439825 | 0.72 | NR4A2 (0.60) | KDM4ENOS2NOS1NOS3MCHR1 | |
| SCHEMBL438834 | 0.72 | NOS2 (0.50) | KDM4ENOS2NOS1NOS3MCHR1 | |
| SCHEMBL438887 | 0.72 | MCHR1 (0.44) | KDM4ENOS2NOS1NOS3MCHR1 | |
| SCHEMBL441901 | 0.70 | MCHR1 (0.43) | POLBKDM4ENOS2NOS1NOS3 | |
| SCHEMBL439708 | 0.70 | MCHR1 (0.43) | POLBNOS2NOS1NOS3MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120065166-A1 | Bone Modulators And Methods Therewith | ESPINA VIRGINIA (US) | 2012-03-15 | — | — | US | disclosed |