Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.34 |
| ▸ | PGK1 | P00558 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL436991 | 0.86 | NOS3 (0.41) | MAPTLMNANOS3NOS1NOS2 | |
| SCHEMBL438207 | 0.79 | MAPT (0.53) | MAPTMEN1KMT2AGAANPC1 | |
| SCHEMBL441787 | 0.77 | MCHR1 (0.37) | MAPTMAPK1MEN1LMNAKMT2A | |
| SCHEMBL439849 | 0.76 | POLB (0.43) | MAPTKDM4ELMNANOS3NOS1 | |
| SCHEMBL438754 | 0.72 | HSP90AB1 (0.52) | KDM4ESMN1; SMN2HSD17B10MCHR1ALDH1A1 | |
| SCHEMBL438225 | 0.71 | MCHR1 (0.42) | MAPTLMNANOS3NOS1NOS2 | |
| SCHEMBL439825 | 0.71 | NR4A2 (0.60) | MAPTKDM4ENOS3NOS1NOS2 | |
| SCHEMBL439885 | 0.70 | NOS3 (0.41) | NOS3NOS1NOS2NPC1MCHR1 | |
| SCHEMBL439708 | 0.70 | MCHR1 (0.43) | MAPTLMNANOS3NOS1NOS2 | |
| SCHEMBL441901 | 0.67 | MCHR1 (0.43) | MAPTKDM4ELMNANOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120065166-A1 | Bone Modulators And Methods Therewith | ESPINA VIRGINIA (US) | 2012-03-15 | — | — | US | disclosed |