Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 4/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL577677 | 0.72 | HTR6 (0.31) | — | |
| SCHEMBL577679 | 0.72 | HTR6 (0.31) | — | |
| SCHEMBL11975940 | 0.72 | HDAC4 (0.33) | KDM4EMAPTPOLBKMT2AMEN1 | |
| SCHEMBL8249373 | 0.71 | DPP4 (0.37) | KDM4EMAPTPOLBKMT2AMEN1 | |
| SCHEMBL14216851 | 0.70 | ALDH1A1 (0.33) | KDM4ELMNAPOLBPKMALDH1A1 | |
| SCHEMBL2012122 | 0.70 | L3MBTL3 (0.31) | L3MBTL1 | |
| SCHEMBL2012118 | 0.70 | L3MBTL3 (0.31) | L3MBTL1 | |
| SCHEMBL2012120 | 0.70 | L3MBTL3 (0.31) | L3MBTL1 | |
| Hydrochloric Acid SCHEMBL29716176 | 0.69 | L3MBTL3 (0.30) | L3MBTL1 | |
| SCHEMBL5609602 | 0.69 | KDM4E (0.44) | KDM4ELMNAMAPTPOLBPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118091-A1 | PYRIMIDINE SUBSTITUTED MACROCYCLIC HCV INHIBITORS | Tibotec Pharmaceuticals (IE) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008095999-A1 | PYRIMIDINE SUBSTITUTED MACROCYCLIC HCV INHIBITORS | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2008-08-14 | — | — | WO | disclosed |