SCHEMBL4403373

SCHEMBL4403373

CC(C)C(=O)NCc1cccc2ccccc12

nearest known ligand 0.70

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ANPEP P15144 1/20 0.61
KMT2A Q03164 2/20 0.59
MEN1 O00255 1/20 0.59
MAPT P10636 1/20 0.59
KDM4E B2RXH2 1/20 0.55
ALDH1A1 P00352 1/20 0.55
TDP1 Q9NUW8 1/20 0.55
MTNR1A P48039 2/20 0.54
CHRNB2 P17787 1/20 0.54
CHRNA4 P43681 1/20 0.54
BCHE P06276 1/20 0.51
CA2 P00918 1/20 0.51
ATM Q13315 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16899301 0.90 ANPEP (0.55) ANPEPKMT2AMEN1MAPTKDM4E
SCHEMBL16908240 0.89 CARM1 (0.60) ANPEPKMT2AMEN1MAPTKDM4E
SCHEMBL16899278 0.89 CARM1 (0.60) ANPEPKMT2AMEN1MAPTKDM4E
SCHEMBL12863555 0.88 ANPEP (0.56) ANPEPKMT2AMEN1MAPTKDM4E
SCHEMBL14108271 0.86 ANPEP (0.55) ANPEPKMT2AMEN1MAPTKDM4E
SCHEMBL16908117 0.86 ANPEP (0.55) ANPEPKMT2AMEN1MAPTKDM4E
SCHEMBL18812522 0.86 ANPEP (0.55) ANPEPKMT2AMEN1MAPTKDM4E
SCHEMBL18787152 0.85 ANPEP (0.57) ANPEPKMT2AMEN1MAPTKDM4E
SCHEMBL16899284 0.85 ANPEP (0.57) ANPEPKMT2AMEN1MAPTKDM4E
SCHEMBL1566774 0.84 MEN1 (0.64) ANPEPKMT2AMEN1MAPTTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 80 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240218374-A1 Nucleic Acid Compounds That Bind Coronavirus Proteins SOMALOGIC OPERATING CO., INC. (US) 2024-07-04 US disclosed
US-20240218374-A1 Nucleic Acid Compounds That Bind Coronavirus Proteins SOMALOGIC OPERATING CO., INC. (US) 2024-07-04 US disclosed
US-11834515-B2 Macrocyclic compounds as proteasome inhibitors CORNELL UNIVERSITY (US) 2023-12-05 US disclosed
US-20230193287-A1 Nucleic Acid Compounds for Binding Growth Differentiation Factor 11 SOMALOGIC OPERATING CO., INC. (US) 2023-06-22 US disclosed
US-11597727-B2 Inhibitors of integrin alpha 2 beta 1 and methods of use THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2023-03-07 US disclosed
US-20230024434-A1 Methods for Developing Personalized Drug Treatment Plans and Targeted Drug Development Based on Proteomic Profiles SOMALOGIC, INC. (US) 2023-01-26 US disclosed
US-20210387986-A1 INHIBITORS OF INTEGRIN ALPHA 2 BETA 1 AND METHODS OF USE THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2021-12-16 US disclosed
US-11111495-B2 Method for generating aptamers with improved off-rates SOMALOGIC, INC. (US) 2021-09-07 US disclosed
US-10544419-B2 PDGF and VEGF aptamers having improved stability and their use in treating PDGF and VEGF mediated diseases and disorders SOMALOGIC INC. (US) 2020-01-28 US disclosed
US-20190330634-A1 Method for Generating Aptamers with Improved Off-Rates SOMALOGIC OPERATING CO., INC. 2019-10-31 US disclosed
US-20110082286-A1 Method for Generating Aptamers with Improved Off-Rates SOMALOGIC, INC. (US) 2011-04-07 US disclosed
US-20110082286-A1 Method for Generating Aptamers with Improved Off-Rates SOMALOGIC, INC. (US) 2011-04-07 US disclosed
WO-2011006075-A1 METHOD FOR GENERATING APTAMERS WITH IMPROVED OFF-RATES SOMALOGIC, INC. (US) 2011-01-13 WO disclosed
US-7855054-B2 Multiplexed analyses of test samples SOMALOGIC, INC. (US) 2010-12-21 US disclosed
US-7855054-B2 Multiplexed analyses of test samples SOMALOGIC, INC. (US) 2010-12-21 US disclosed
US-7402690-B2 Chain transfer agents for raft polymerization in aqueous media UNIVERSITY OF SOUTHERN MISSISSIPPI (US) 2008-07-22 US disclosed
US-20070265263-A1 Heterocyclic inhibitors of ERK2 and uses thereof CAO JINGRONG 2007-11-15 US disclosed
US-7253187-B2 Heterocyclic inhibitors of ERK2 and uses thereof VERTEX PHARMACEUTICALS INCORPORATED (US) 2007-08-07 US disclosed
US-20070123670-A1 Chain transfer agents for raft polymerization in aqueous media MCCORMICK CHARLES L 2007-05-31 US disclosed
US-20070078146-A1 Antiinflamamtory agents; antiarthritic agents; inflammatory bowel disorders; multiple sclerosis; asthma PHARMACIA CORPORATION 2007-04-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070265263-A1 Heterocyclic inhibitors of ERK2 and uses thereof MAPK1, MAPK3, MAPKAPK2 ANPEP 3964/4885KMT2A 2432/4885MEN1 2607/4885
US-20230193287-A1 Nucleic Acid Compounds for Binding Growth Differentiation Factor 11 MSTN, S100A11, IGF2BP1 ANPEP 333/4885KMT2A 3322/4885MEN1 1586/4885
US-11597727-B2 Inhibitors of integrin alpha 2 beta 1 and methods of use ITGB1, ITGB2, ITGA2 ANPEP 881/4885KMT2A 3209/4885MEN1 4127/4885
US-20210387986-A1 INHIBITORS OF INTEGRIN ALPHA 2 BETA 1 AND METHODS OF USE ITGB1, ITGB2, ITGA2 ANPEP 881/4885KMT2A 3209/4885MEN1 4127/4885
US-20110082286-A1 Method for Generating Aptamers with Improved Off-Rates DDX1, DDX3X, DDX18 ANPEP 220/4885KMT2A 1608/4885MEN1 4259/4885
US-11834515-B2 Macrocyclic compounds as proteasome inhibitors PSMB5, PSMB1, PSMB3 ANPEP 2455/4885KMT2A 1548/4885MEN1 1227/4885
US-20240218374-A1 Nucleic Acid Compounds That Bind Coronavirus Proteins SARS1, RNGTT, PABPC1 ANPEP 42/4885KMT2A 3666/4885MEN1 4651/4885
US-20070078146-A1 Antiinflamamtory agents; antiarthritic agents; inflammatory bowel disorders; multiple sclerosis; asthma MAPK1, MAPK3, MAPK4 ANPEP 3847/4885KMT2A 1449/4885MEN1 3032/4885
US-20230024434-A1 Methods for Developing Personalized Drug Treatment Plans and Targeted Drug Development Based on Proteomic Profiles TTR, TPX2, FABP1 ANPEP 118/4885KMT2A 3305/4885MEN1 4410/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.