SCHEMBL4406496

SCHEMBL4406496

CCCC1(C(=O)O)CCCN1

nearest known ligand 0.58

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
ARG1 P05089 2/20 0.58
ARG2 P78540 2/20 0.58
SLC6A2 P23975 11/20 0.51
SLC6A4 P31645 11/20 0.51
SLC6A3 Q01959 11/20 0.51
CYP2D6 P10635 10/20 0.51
KCNH2 Q12809 2/20 0.51
HRH3 Q9Y5N1 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11650757 1.00 ARG1 (0.58) ARG1ARG2SLC6A2SLC6A4SLC6A3
SCHEMBL15664945 0.89 ARG2 (0.64) ARG1ARG2SLC6A2SLC6A4SLC6A3
SCHEMBL1359695 0.84 ARG1 (0.53) ARG1ARG2SLC6A2SLC6A4SLC6A3
SCHEMBL1359692 0.84 ARG1 (0.53) ARG1ARG2SLC6A2SLC6A4SLC6A3
SCHEMBL30085352 0.84 ARG1 (0.53) ARG1ARG2SLC6A2SLC6A4SLC6A3
SCHEMBL7094527 0.82 ARG2 (0.60) ARG1ARG2SLC6A2SLC6A4SLC6A3
Hydrochloric Acid SCHEMBL11652154 0.80 CYP2D6 (0.48) ARG1ARG2SLC6A2SLC6A4SLC6A3
SCHEMBL15854605 0.80 ARG2 (0.54) ARG1ARG2SLC6A2SLC6A4SLC6A3
SCHEMBL17393299 0.79 SLC6A4 (0.47) ARG1ARG2SLC6A2SLC6A4SLC6A3
SCHEMBL31106404 0.78 ARG1 (0.47) ARG1ARG2SLC6A2SLC6A4SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3154568-A1 NON-CANONICAL INSULINS AND THEIR USES California Institute of Technology (US) 2017-04-19 EP claimed
WO-2015191705-A1 NON-CANONICAL INSULINS AND THEIR USES CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2015-12-17 WO claimed
US-20150353619-A1 Non-Canonical Insulins and Their Uses CALIFORNIA INSTITUTE OF TECHNOLOGY 2015-12-10 US claimed
CN-122055379-A Compounds containing one or more diboronate esters and related insulin analogues 普罗托莫科技公司 2026-05-15 CN disclosed
EP-4694932-A2 COMPOUNDS CONTAINING ONE OR MORE DIBORONATES AND RELATED INSULIN ANALOGS Protomer Technologies Inc. (US) 2026-02-18 EP disclosed
US-20250249074-A1 GLUCOSE RESPONSIVE INSULINS PROTOMER TECHNOLOGIES INC. 2025-08-07 US disclosed
CN-119677541-A Aromatic boron-containing compounds and related insulin analogues 原聚体科技公司 2025-03-21 CN disclosed
US-12214018-B2 Glucose responsive insulins PROTOMER TECHNOLOGIES, INC. (US) 2025-02-04 US disclosed
US-20240425528-A1 AROMATIC BORON-CONTAINING COMPOUNDS AND RELATED INSULIN ANALOGS PROTOMER TECH INC (US) 2024-12-26 US disclosed
US-20240400637-A1 COMPOUNDS CONTAINING ONE OR MORE DIBORONATES AND RELATED INSULIN ANALOGS PROTOMER TECHNOLOGIES INC. 2024-12-05 US disclosed
US-20240374735-A1 AROMATIC BORON-CONTAINING COMPOUNDS AND INSULIN ANALOGS PROTOMER TECHNOLOGIES INC. 2024-11-14 US disclosed
US-10640546-B2 Non-canonical insulins and their uses CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2020-05-05 US disclosed
US-20190247468-A1 GLUCOSE RESPONSIVE INSULINS PROTOMER TECHNOLOGIES, INC. 2019-08-15 US disclosed
EP-3291828-A1 GLUCOSE RESPONSIVE INSULINS Mahdavi, Alborz (US) 2018-03-14 EP disclosed
WO-2016179568-A1 GLUCOSE RESPONSIVE INSULINS PROTOMER TECHNOLOGIES, INC. (US) 2016-11-10 WO disclosed
US-20150353619-A1 Non-Canonical Insulins and Their Uses CALIFORNIA INSTITUTE OF TECHNOLOGY 2015-12-10 US disclosed
US-7589066-B2 Such as N-carbobenzyloxy-phenylalanyl-phenylalanylal; for treating cancer, inflammation, and/or autoimmune diseases; suppresses endogenous antigenic peptide generation THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2009-09-15 US disclosed
EP-1863513-A2 POTENT AND SPECIFIC IMMUNOPROTEASOME INHIBITORS The University of North Carolina at Chapel Hill (US) 2007-12-12 EP disclosed
US-20060241056-A1 Potent and specific immunoproteasome inhibitors UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL 2006-10-26 US disclosed
WO-2006099261-A2 POTENT AND SPECIFIC IMMUNOPROTEASOME INHIBITORS THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2006-09-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060241056-A1 Potent and specific immunoproteasome inhibitors SERPINB1, DNPEP, PSMB2 ARG1 1597/4885ARG2 1948/4885SLC6A2 4813/4885
US-20190247468-A1 GLUCOSE RESPONSIVE INSULINS GLP1R, GPR119, IAPP ARG1 2266/4885ARG2 2786/4885SLC6A2 2935/4885
US-20250249074-A1 GLUCOSE RESPONSIVE INSULINS GLP1R, GPR119, IAPP ARG1 2202/4885ARG2 2799/4885SLC6A2 2940/4885
US-20240425528-A1 AROMATIC BORON-CONTAINING COMPOUNDS AND RELATED INSULIN ANALOGS IAPP, GPR119, INSR ARG1 2742/4885ARG2 2052/4885SLC6A2 554/4885
US-12214018-B2 Glucose responsive insulins GLP1R, GPR119, IAPP ARG1 2266/4885ARG2 2786/4885SLC6A2 2935/4885
US-20150353619-A1 Non-Canonical Insulins and Their Uses IAPP, IDE, INSR ARG1 415/4885ARG2 478/4885SLC6A2 2907/4885
US-20240400637-A1 COMPOUNDS CONTAINING ONE OR MORE DIBORONATES AND RELATED INSULIN ANALOGS GPR119, INSR, IAPP ARG1 402/4885ARG2 281/4885SLC6A2 680/4885
US-20240374735-A1 AROMATIC BORON-CONTAINING COMPOUNDS AND INSULIN ANALOGS IAPP, GPR119, BRCA1 ARG1 269/4885ARG2 190/4885SLC6A2 216/4885
US-10640546-B2 Non-canonical insulins and their uses IAPP, IDE, INSR ARG1 415/4885ARG2 478/4885SLC6A2 2907/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.