Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.44 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | APEX1 | P27695 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 2/20 | 0.44 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.38 |
| ▸ | TOP1 | P11387 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4409742 | 1.00 | BLM (0.44) | BLMTSHRGABRR1GABRR2LMNA | |
| SCHEMBL2382740 | 0.97 | TSHR (0.46) | BLMTSHRGABRR1GABRR2LMNA | |
| SCHEMBL2382741 | 0.97 | TSHR (0.46) | BLMTSHRGABRR1GABRR2LMNA | |
| Hydrochloric Acid SCHEMBL2558275 | 0.95 | TSHR (0.44) | BLMTSHRGABRR1GABRR2LMNA | |
| SCHEMBL28170874 | 0.91 | TOP1 (0.50) | BLMLMNAAPEX1NPSR1TDP1 | |
| SCHEMBL11535812 | 0.88 | PTPN1 (0.46) | BLMTSHRGABRR1GABRR2LMNA | |
| SCHEMBL27995449 | 0.88 | BLM (0.42) | BLMTSHRGABRR1GABRR2LMNA | |
| SCHEMBL7746003 | 0.88 | BLM (0.42) | BLMTSHRGABRR1GABRR2LMNA | |
| SCHEMBL8551677 | 0.87 | TSHR (0.55) | BLMTSHRGABRR1GABRR2LMNA | |
| SCHEMBL8551672 | 0.87 | TSHR (0.55) | BLMTSHRGABRR1GABRR2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030068330-A1 | Nerve growth factor activity potentiating agents | HISAMITSU PHARMACEUTICAL CO., INC. (JP) | 2003-04-10 | — | — | US | claimed |
| EP-1293200-A1 | NERVE GROWTH FACTOR ACTIVITY POTENTIATING AGENTS | HISAMITSU PHARMACEUTICAL CO. INC. (JP) | 2003-03-19 | — | — | EP | claimed |
| EP-2112135-B1 | E2, E4,Z8-undecatrienoic acid and ester and carboxamide derivatives thereof, organoleptic uses thereof and processes for preparing same | INT FLAVORS & FRAGRANCES INC (US) | 2013-06-19 | — | — | EP | disclosed |
| EP-1496042-B1 | E2, E4,Z8-Undecatrienoic acid and ester and carboxamide derivatives thereof, organoleptic uses thereof and processes for preparing same | INT FLAVORS & FRAGRANCES INC (US) | 2009-11-11 | — | — | EP | disclosed |
| EP-2112135-A2 | E2, E4,Z8-undecatrienoic acid and ester and carboxamide derivatives thereof, organoleptic uses thereof and processes for preparing same | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 2009-10-28 | — | — | EP | disclosed |
| US-7534817-B1 | Kombic acid/sarganol bis-succinate and derivatives as potent apoptogens (antineoplastic agents) with high selectivity for cancer cells | LEONARD EDWARD C | 2009-05-19 | — | — | US | disclosed |
| US-7141686-B2 | E2, E4, Z8-undecatrienoic acid and ester and carboxamide derivatives thereof, organoleptic uses thereof and processes for preparing same | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 2006-11-28 | — | — | US | disclosed |
| US-7098350-B2 | E2,E4,Z8-undecatrienoic acid and ester and carboxamide derivatives thereof, organoleptic uses thereof and processes for preparing same | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 2006-08-29 | — | — | US | disclosed |
| US-20050197387-A1 | E2,E4,Z8-undecatrienoic acid and ester and carboxamide derivatives thereof, organoleptic uses thereof and processes for preparing same | INTERNATIONAL FLAVORS & FRAGARANCES INC. | 2005-09-08 | — | — | US | disclosed |
| US-20050192343-A1 | Nerve growth factor activity potentiating agents | GOTO TAKESHI (JP) | 2005-09-01 | — | — | US | disclosed |
| US-20050010062-A1 | E2,E4,Z8-UNDECATRIENOIC ACID AND ESTER AND CARBOXAMIDE DERIVATIVES THEREOF, ORGANOLEPTIC USES THEREOF AND PROCESSES FOR PREPARING SAME | INTERNATIONAL FLAVORS & FRAGRANCES INC. | 2005-01-13 | — | — | US | disclosed |
| EP-1496042-A2 | E2, E4,Z8-Undecatrienoic acid and ester and carboxamide derivatives thereof, organoleptic uses thereof and processes for preparing same | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 2005-01-12 | — | — | EP | disclosed |
| US-20030068330-A1 | Nerve growth factor activity potentiating agents | HISAMITSU PHARMACEUTICAL CO., INC. (JP) | 2003-04-10 | — | — | US | disclosed |
| EP-1293200-A1 | NERVE GROWTH FACTOR ACTIVITY POTENTIATING AGENTS | HISAMITSU PHARMACEUTICAL CO. INC. (JP) | 2003-03-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050192343-A1 | Nerve growth factor activity potentiating agents | BDNF, NGF, HDGF | BLM 4854/4885TSHR 3475/4885GABRR1 1673/4885 |
| US-20050010062-A1 | E2,E4,Z8-UNDECATRIENOIC ACID AND ESTER AND CARBOXAMIDE DERIVATIVES THEREOF, ORGANOLEPTIC USES THEREOF AND PROCESSES FOR PREPARING SAME | ESRRA, TECR, TAS2R8 | BLM 4612/4885TSHR 457/4885GABRR1 771/4885 |
| US-20030068330-A1 | Nerve growth factor activity potentiating agents | BDNF, NGF, OGFR | BLM 4814/4885TSHR 3510/4885GABRR1 1752/4885 |
| US-20050197387-A1 | E2,E4,Z8-undecatrienoic acid and ester and carboxamide derivatives thereof, organoleptic uses thereof and processes for preparing same | UBE4A, TAS2R8, CUTA | BLM 4841/4885TSHR 2983/4885GABRR1 4088/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.