Sugi Predict

Sugi Predict / Compounds / SCHEMBL4409953

SCHEMBL4409953

SCHEMBL4409953

CCC[C@@H]1CC(=O)N([C@H](CC)C(=O)OC)C1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ BRD4 O60885 4/20 0.38
▸ CA1 P00915 2/20 0.34
▸ CA2 P00918 2/20 0.34
▸ TSHR P16473 1/20 0.34
▸ LMNA P02545 1/20 0.33
▸ CA12 O43570 1/20 0.33
▸ CA3 P07451 1/20 0.33
▸ CA4 P22748 1/20 0.33
▸ CA6 P23280 1/20 0.33
▸ CA5A P35218 1/20 0.33
▸ CA7 P43166 1/20 0.33
▸ CA9 Q16790 1/20 0.33
▸ CA13 Q8N1Q1 1/20 0.33
▸ CA14 Q9ULX7 1/20 0.33
▸ CA5B Q9Y2D0 1/20 0.33
▸ MAPT P10636 1/20 0.33
▸ POLB P06746 2/20 0.32
▸ ALDH1A1 P00352 2/20 0.32
▸ L3MBTL1 Q9Y468 1/20 0.32
▸ SMN1; SMN2 Q16637 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28351910 1.00 BRD4 (0.38) BRD4CA1CA2TSHRLMNA
SCHEMBL20225963 1.00 BRD4 (0.38) BRD4CA1CA2TSHRLMNA
SCHEMBL13596600 1.00 BRD4 (0.38) BRD4CA1CA2TSHRLMNA
SCHEMBL8350417 1.00 BRD4 (0.38) BRD4CA1CA2TSHRLMNA
SCHEMBL14282520 1.00 BRD4 (0.38) BRD4CA1CA2TSHRLMNA
SCHEMBL29809272 1.00 BRD4 (0.38) BRD4CA1CA2TSHRLMNA
SCHEMBL8352237 0.89 BRD4 (0.36) BRD4CA1CA2TSHRLMNA
SCHEMBL30885557 0.86 ALDH1A1 (0.38) BRD4CA1CA2TSHRLMNA
SCHEMBL14048425 0.86 LMNA (0.35) BRD4CA1CA2TSHRLMNA
SCHEMBL8350327 0.86 BRD4 (0.38) BRD4CA1CA2TSHRLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8957226-B2 2-oxo-1-pyrrolidine derivatives, processes for preparing them and their uses UCB PHARMA S.A. (BE) 2015-02-17 — — US disclosed
US-8957226-B2 2-oxo-1-pyrrolidine derivatives, processes for preparing them and their uses UCB PHARMA S.A. (BE) 2015-02-17 — — US disclosed
US-8957226-B2 2-oxo-1-pyrrolidine derivatives, processes for preparing them and their uses UCB PHARMA S.A. (BE) 2015-02-17 — — US disclosed
US-20090318708-A1 2-Oxo-1-Pyrrolidine Derivatives, Processes For Preparing Them And Their Uses UCB BIOPHARMA SPRL (BE) 2009-12-24 — — US disclosed
US-20090318708-A1 2-Oxo-1-Pyrrolidine Derivatives, Processes For Preparing Them And Their Uses UCB BIOPHARMA SPRL (BE) 2009-12-24 — — US disclosed
US-20090318708-A1 2-Oxo-1-Pyrrolidine Derivatives, Processes For Preparing Them And Their Uses UCB BIOPHARMA SPRL (BE) 2009-12-24 — — US disclosed
EP-1926710-A1 4-SUBSTITUTED PYRR0LIDIN-2-0NES AND THEIR USE UCB, S.A. (BE) 2008-06-04 — — EP disclosed
WO-2007031263-A1 4-SUBSTITUTED PYRR0LIDIN-2-0NES AND THEIR USE UCB PHARMA, S.A. (BE) 2007-03-22 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090318708-A1 2-Oxo-1-Pyrrolidine Derivatives, Processes For Preparing Them And Their Uses PPOX, PYCR1, ALDH18A1 BRD4 1198/4885CA1 4726/4885CA2 4024/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.