Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 3/20 | 0.36 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.34 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.34 |
| ▸ | NR4A2 | P43354 | 4/20 | 0.33 |
| ▸ | JAK2 | O60674 | 3/20 | 0.33 |
| ▸ | JAK3 | P52333 | 3/20 | 0.33 |
| ▸ | NHERF1 | O14745 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 2/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1306128 | 0.79 | IRAK4 (0.39) | SYKEGFRERBB2ERBB4ROCK2 | |
| SCHEMBL4412798 | 0.77 | ROCK1 (0.50) | EGFRAURKAROCK1 | |
| SCHEMBL4428827 | 0.76 | EGFR (0.50) | SYKEGFR | |
| SCHEMBL4414311 | 0.73 | EGFR (0.53) | SYKALDH1A1EGFRROCK2 | |
| SCHEMBL4427810 | 0.71 | EGFR (0.45) | SYKEGFR | |
| SCHEMBL4411564 | 0.70 | CDC7 (0.49) | SYKALDH1A1ATMEGFRJAK3 | |
| SCHEMBL4417948 | 0.69 | GAA (0.43) | JAK2JAK3AURKAROCK1 | |
| SCHEMBL4414428 | 0.69 | EGFR (0.47) | EGFRERBB2 | |
| SCHEMBL4413885 | 0.68 | FYN (0.46) | ALDH1A1JAK2JAK3AURKAAURKB | |
| SCHEMBL4420185 | 0.68 | ROCK1 (0.49) | SYKEGFRERBB2ERBB4ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7601713-B2 | Kinase inhibitors and their uses | RIGEL PHARMACEUTICALS, INC. (US) | 2009-10-13 | — | — | US | claimed |