SCHEMBL4411449

SCHEMBL4411449

Cc1cn(CC(=O)N(CCNS(=O)(=O)c2nnc(-c3ccc([N+](=O)[O-])cc3Cl)s2)CC(=O)O)c(=O)[nH]c1=O

nearest known ligand 0.33

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
KMT2A Q03164 3/20 0.32
MAPT P10636 3/20 0.32
MEN1 O00255 2/20 0.32
KDM4E B2RXH2 1/20 0.32
ALDH1A1 P00352 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4421554 0.94 SMN1; SMN2 (0.33) LMNASMN1; SMN2KMT2AMAPTMEN1
SCHEMBL4418155 0.91 TK2 (0.33) MAPTKDM4E
SCHEMBL4419177 0.90 CA12 (0.32) LMNASMN1; SMN2KMT2AMAPTMEN1
SCHEMBL4416110 0.89 MAPT (0.36) LMNAKMT2AMAPTMEN1
SCHEMBL4425387 0.86 TK1 (0.33)
SCHEMBL4415442 0.84 MAPT (0.34) KMT2AMAPTMEN1KDM4E
SCHEMBL4414566 0.83 CA12 (0.38)
SCHEMBL4426611 0.83 ALDH1A1 (0.33) KMT2AMEN1ALDH1A1
SCHEMBL4412201 0.82 RAB9A (0.37) LMNASMN1; SMN2KMT2AMAPTMEN1
SCHEMBL4414797 0.82 TK1 (0.37)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1651642-B1 PNA MONOMER AND PRECURSOR PANAGENE INC (KR) 2009-11-04 EP disclosed
US-7211668-B2 PNA monomer and precursor PANAGENE, INC. (KR) 2007-05-01 US disclosed
EP-1651642-A4 PNA MONOMER AND PRECURSOR PANAGENE INC (KR) 2006-11-29 EP disclosed
EP-1651642-A1 PNA MONOMER AND PRECURSOR Panagene Inc. (KR) 2006-05-03 EP disclosed
US-20050026930-A1 PNA monomer and precursor PANAGENE, INC. (KR) 2005-02-03 US disclosed
WO-2005009998-A1 PNA MONOMER AND PRECURSOR PANAGENE INC. (US) 2005-02-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050026930-A1 PNA monomer and precursor RNGTT, POLL, NSUN3 LMNA 236/4885SMN1; SMN2 1750/4885KMT2A 4464/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.