SCHEMBL4418155

SCHEMBL4418155

Cc1cn(CC(=O)N(CCNS(=O)(=O)c2nnc(-c3ccc(Cl)cc3Cl)s2)CC(=O)O)c(=O)[nH]c1=O

nearest known ligand 0.33

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
TK2 O00142 2/20 0.33
CA12 O43570 1/20 0.33
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
CA9 Q16790 1/20 0.33
KDM4E B2RXH2 1/20 0.32
MAPT P10636 1/20 0.32
TK1 P04183 1/20 0.32
SHMT1 P34896 1/20 0.30
SHMT2 P34897 1/20 0.30
PTPRB P23467 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4425387 0.94 TK1 (0.33) TK2CA12CA1CA2CA9
SCHEMBL4415442 0.93 MAPT (0.34) TK2CA12CA1CA2CA9
SCHEMBL4411449 0.91 LMNA (0.33) KDM4EMAPT
SCHEMBL4419177 0.91 CA12 (0.32) TK2CA12CA1CA2CA9
SCHEMBL4414566 0.90 CA12 (0.38) TK2CA12CA1CA2CA9
SCHEMBL4412301 0.87 KMT2A (0.33) TK2CA12CA1CA2CA9
SCHEMBL4414797 0.86 TK1 (0.37) TK2CA12CA1CA2CA9
SCHEMBL4426611 0.84 ALDH1A1 (0.33) CA12CA1CA2CA9
SCHEMBL4421554 0.84 SMN1; SMN2 (0.33) KDM4EMAPT
SCHEMBL4415959 0.83 DDX3X (0.34) TK2CA12CA1CA2CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1651642-B1 PNA MONOMER AND PRECURSOR PANAGENE INC (KR) 2009-11-04 EP disclosed
US-7211668-B2 PNA monomer and precursor PANAGENE, INC. (KR) 2007-05-01 US disclosed
EP-1651642-A4 PNA MONOMER AND PRECURSOR PANAGENE INC (KR) 2006-11-29 EP disclosed
EP-1651642-A1 PNA MONOMER AND PRECURSOR Panagene Inc. (KR) 2006-05-03 EP disclosed
US-20050026930-A1 PNA monomer and precursor PANAGENE, INC. (KR) 2005-02-03 US disclosed
WO-2005009998-A1 PNA MONOMER AND PRECURSOR PANAGENE INC. (US) 2005-02-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050026930-A1 PNA monomer and precursor RNGTT, POLL, NSUN3 TK2 2416/4885CA12 3059/4885CA1 1963/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.