SCHEMBL4415442

SCHEMBL4415442

CCOC(=O)CN(CCNS(=O)(=O)c1nnc(-c2ccc(Cl)cc2Cl)s1)C(=O)Cn1cc(C)c(=O)[nH]c1=O

nearest known ligand 0.34

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.34
KDM4E B2RXH2 1/20 0.34
ITGB2 P05107 1/20 0.32
ITGAM P11215 1/20 0.32
CA12 O43570 1/20 0.32
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
CA9 Q16790 1/20 0.32
TSHR P16473 1/20 0.32
KMT2A Q03164 2/20 0.32
MEN1 O00255 1/20 0.32
POLB P06746 1/20 0.32
TK1 P04183 1/20 0.31
HTT P42858 1/20 0.31
CDC7 O00311 1/20 0.31
DBF4 Q9UBU7 1/20 0.31
PTPRB P23467 1/20 0.31
TK2 O00142 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4412301 0.94 KMT2A (0.33) CA12CA1CA2CA9KMT2A
SCHEMBL4418155 0.93 TK2 (0.33) MAPTKDM4ECA12CA1CA2
SCHEMBL4426611 0.91 ALDH1A1 (0.33) CA12CA1CA2CA9KMT2A
SCHEMBL4421554 0.91 SMN1; SMN2 (0.33) MAPTKDM4EKMT2AMEN1
SCHEMBL4415591 0.90 CA12 (0.37) CA12CA1CA2CA9TSHR
SCHEMBL4425387 0.87 TK1 (0.33) CA12CA1CA2CA9TK1
SCHEMBL4414309 0.86 TK1 (0.36) CA12CA1CA2CA9TSHR
SCHEMBL4411449 0.84 LMNA (0.33) MAPTKDM4EKMT2AMEN1
SCHEMBL4419177 0.84 CA12 (0.32) MAPTKDM4ECA12CA1CA2
SCHEMBL4418646 0.84 DDX3X (0.33) MAPTCA12CA1CA2CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1651642-B1 PNA MONOMER AND PRECURSOR PANAGENE INC (KR) 2009-11-04 EP disclosed
US-7211668-B2 PNA monomer and precursor PANAGENE, INC. (KR) 2007-05-01 US disclosed
EP-1651642-A4 PNA MONOMER AND PRECURSOR PANAGENE INC (KR) 2006-11-29 EP disclosed
EP-1651642-A1 PNA MONOMER AND PRECURSOR Panagene Inc. (KR) 2006-05-03 EP disclosed
US-20050026930-A1 PNA monomer and precursor PANAGENE, INC. (KR) 2005-02-03 US disclosed
WO-2005009998-A1 PNA MONOMER AND PRECURSOR PANAGENE INC. (US) 2005-02-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050026930-A1 PNA monomer and precursor RNGTT, POLL, NSUN3 MAPT 4633/4885KDM4E 4872/4885ITGB2 2219/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.