Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4551944 | 0.89 | NR1H4 (0.46) | MEN1KMT2AMAPTRAF1BRAF | |
| SCHEMBL4412543 | 0.87 | ALDH1A1 (0.42) | MEN1KMT2AMAPTRAF1BRAF | |
| SCHEMBL4409369 | 0.86 | RAB9A (0.51) | MEN1KMT2ARAF1BRAFTSHR | |
| SCHEMBL4419761 | 0.86 | CYP1A2 (0.49) | MEN1KMT2AMAPTGAATSHR | |
| SCHEMBL4415213 | 0.86 | RAF1 (0.45) | MEN1KMT2AMAPTRAF1BRAF | |
| SCHEMBL4411086 | 0.86 | NR1H4 (0.46) | MEN1KMT2AMAPTRAF1BRAF | |
| SCHEMBL4407658 | 0.85 | NPC1 (0.42) | MEN1KMT2ABRAFGAATSHR | |
| SCHEMBL4420074 | 0.85 | RAF1 (0.49) | RAF1BRAFRXFP1KDM4E | |
| SCHEMBL4411132 | 0.84 | BRAF (0.38) | MEN1KMT2AMAPTRAF1BRAF | |
| SCHEMBL4551235 | 0.84 | MEN1 (0.50) | MEN1KMT2AMAPTRXFP1NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007075896-A2 | HETEROCYCLIC CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |