Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 4/20 | 0.49 |
| ▸ | BRAF | P15056 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.43 |
| ▸ | BCL3 | P20749 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4415213 | 0.85 | RAF1 (0.45) | RAF1BRAFNPC1RAB9ARXFP1 | |
| SCHEMBL4411700 | 0.85 | MEN1 (0.43) | RAF1BRAFKDM4ERXFP1 | |
| SCHEMBL4413480 | 0.84 | RAF1 (0.45) | RAF1BRAFNPC1RXFP1MAPK14 | |
| SCHEMBL4412543 | 0.84 | ALDH1A1 (0.42) | RAF1BRAFNPC1POLBRAB9A | |
| SCHEMBL4409369 | 0.82 | RAB9A (0.51) | RAF1BRAFL3MBTL1NPC1RAB9A | |
| SCHEMBL4551944 | 0.82 | NR1H4 (0.46) | RAF1BRAFRXFP1 | |
| SCHEMBL4407658 | 0.81 | NPC1 (0.42) | BRAFL3MBTL1NPC1RAB9A | |
| SCHEMBL4419761 | 0.79 | CYP1A2 (0.49) | L3MBTL1NPC1POLBRAB9ALMNA | |
| SCHEMBL5593418 | 0.79 | L3MBTL1 (0.44) | RAF1BRAFL3MBTL1NPC1POLB | |
| SCHEMBL5593328 | 0.78 | RXFP1 (0.43) | RAF1BRAFKDM4ERXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |