Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | PTAFR | P25105 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4419761 | 0.93 | CYP1A2 (0.49) | NPC1RAB9ACYP3A4MEN1KMT2A | |
| SCHEMBL4412543 | 0.91 | ALDH1A1 (0.42) | NPC1RAB9ACYP3A4MEN1KMT2A | |
| SCHEMBL4411700 | 0.85 | MEN1 (0.43) | CYP3A4MEN1KMT2ACYP1A2TSHR | |
| SCHEMBL4551944 | 0.82 | NR1H4 (0.46) | MEN1KMT2ATSHRGAABRAF | |
| SCHEMBL4417707 | 0.82 | CYP3A4 (0.43) | RAB9ACYP3A4MEN1KMT2AL3MBTL1 | |
| SCHEMBL4420074 | 0.81 | RAF1 (0.49) | NPC1RAB9AL3MBTL1BRAF | |
| SCHEMBL14473103 | 0.81 | MEN1 (0.46) | NPC1RAB9ACYP3A4MEN1KMT2A | |
| SCHEMBL4415213 | 0.79 | RAF1 (0.45) | NPC1RAB9AMEN1KMT2ABRAF | |
| SCHEMBL4409369 | 0.79 | RAB9A (0.51) | NPC1RAB9AMEN1KMT2AL3MBTL1 | |
| SCHEMBL4410129 | 0.79 | MEN1 (0.44) | NPC1RAB9ACYP3A4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007075896-A2 | HETEROCYCLIC CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007075896-A2 | HETEROCYCLIC CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |