Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 4/20 | 0.45 |
| ▸ | BRAF | P15056 | 3/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 10/20 | 0.43 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.43 |
| ▸ | FRK | P42685 | 1/20 | 0.43 |
| ▸ | HSPB1 | P04792 | 2/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4409369 | 0.90 | RAB9A (0.51) | RAF1BRAFNPC1RAB9AMEN1 | |
| SCHEMBL4413480 | 0.89 | RAF1 (0.45) | RAF1BRAFMAPK14RXFP1NPC1 | |
| SCHEMBL14473322 | 0.87 | MEN1 (0.44) | RAF1BRAFMAPK14EPHA3FRK | |
| SCHEMBL4411700 | 0.86 | MEN1 (0.43) | RAF1BRAFRXFP1MAPTMEN1 | |
| SCHEMBL4420074 | 0.85 | RAF1 (0.49) | RAF1BRAFMAPK14RXFP1NPC1 | |
| SCHEMBL4551944 | 0.83 | NR1H4 (0.46) | RAF1BRAFRXFP1MAPTMEN1 | |
| SCHEMBL4412543 | 0.82 | ALDH1A1 (0.42) | RAF1BRAFRXFP1NPC1RAB9A | |
| SCHEMBL4419761 | 0.81 | CYP1A2 (0.49) | NPC1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL14473317 | 0.80 | RAF1 (0.37) | RAF1BRAFMAPK14EPHA3FRK | |
| SCHEMBL4407658 | 0.79 | NPC1 (0.42) | BRAFNPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007075896-A2 | HETEROCYCLIC CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |