Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | METAP2 | P50579 | 3/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | LSS | P48449 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4422876 | 0.81 | PIK3CG (0.38) | KMT2ANPC1RAB9AHTTSMN1; SMN2 | |
| SCHEMBL4414871 | 0.73 | MAPT (0.45) | ALDH1A1POLBKMT2AMAPTL3MBTL1 | |
| SCHEMBL350889 | 0.73 | IRAK4 (0.41) | ALDH1A1LMNAAURKBHTTSMN1; SMN2 | |
| SCHEMBL350890 | 0.73 | IRAK4 (0.41) | ALDH1A1LMNAAURKBHTTSMN1; SMN2 | |
| SCHEMBL4411964 | 0.71 | TTBK1 (0.49) | POLBMAPTMAPK1AURKBNPC1 | |
| SCHEMBL4428827 | 0.71 | EGFR (0.50) | MAPTNPC1RAB9AFLT1 | |
| SCHEMBL4417948 | 0.71 | GAA (0.43) | KMT2ATDO2MAPTL3MBTL1MAPK1 | |
| SCHEMBL4427810 | 0.70 | EGFR (0.45) | CYP3A4POLBTSHRKMT2AMAPT | |
| SCHEMBL4414428 | 0.70 | EGFR (0.47) | TSHRMAPK1RAB9AHTTSMN1; SMN2 | |
| SCHEMBL4411564 | 0.70 | CDC7 (0.49) | ALDH1A1CYP3A4KMT2AHPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7601713-B2 | Kinase inhibitors and their uses | RIGEL PHARMACEUTICALS, INC. (US) | 2009-10-13 | — | — | US | claimed |