Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8330854 | 1.00 | CA2 (0.46) | CA2ALDH1A1NPSR1CHRM2CHRM4 | |
| SCHEMBL10304985 | 1.00 | CA2 (0.46) | CA2ALDH1A1NPSR1CHRM2CHRM4 | |
| SCHEMBL18817541 | 0.88 | CA2 (0.50) | CA2ALDH1A1NPSR1CHRM2CHRM4 | |
| SCHEMBL7154999 | 0.88 | CA2 (0.50) | CA2ALDH1A1NPSR1CHRM2CHRM4 | |
| SCHEMBL13637952 | 0.87 | ALDH1A1 (0.43) | CA2ALDH1A1NPSR1CHRM2CHRM4 | |
| SCHEMBL10065754 | 0.87 | ALDH1A1 (0.43) | CA2ALDH1A1NPSR1CHRM2CHRM4 | |
| SCHEMBL10972837 | 0.85 | ALDH1A1 (0.52) | CA2ALDH1A1NPSR1CHRM2CHRM4 | |
| SCHEMBL12059431 | 0.85 | ALDH1A1 (0.52) | CA2ALDH1A1NPSR1CHRM2CHRM4 | |
| SCHEMBL13130046 | 0.84 | CA2 (0.47) | CA2ALDH1A1NPSR1CHRM2CHRM4 | |
| SCHEMBL10974424 | 0.84 | ALDH1A1 (0.55) | CA2ALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180141889-A1 | METHODS OF SYNTHESIZING A PROSTACYCLIN ANALOG | CAYMAN CHEMICAL COMPANY INCORPORATED (US) | 2018-05-24 | — | — | US | disclosed |
| US-20180118656-A1 | AMINE SALTS OF A PROSTACYCLIN ANALOG | CAYMAN CHEMICAL COMPANY INCORPORATED (US) | 2018-05-03 | — | — | US | disclosed |
| US-9908834-B2 | Methods of synthesizing a prostacyclin analog | CAYMAN CHEMICAL COMPANY INCORPORATED (US) | 2018-03-06 | — | — | US | disclosed |
| US-9890104-B2 | Amine salts of a prostacyclin analog | CAYMAN CHEMICAL COMPANY INCORPORATED (US) | 2018-02-13 | — | — | US | disclosed |
| US-20170362240-A1 | 4,6-SUBSTITUTED-PYRAZOLO[1,5-a]PYRAZINES AS JANUS KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2017-12-21 | — | — | US | disclosed |
| US-20170297995-A1 | METHODS OF SYNTHESIZING A PROSTACYCLIN ANALOG | CAYMAM CHEMICAL COMPANY INCORPORATED (US) | 2017-10-19 | — | — | US | disclosed |
| WO-2017064701-A1 | METHODS FOR TOTAL SYNTHESIS OF RESOLVIN E1 | SALZMAN LOVELACE INVESTMENTS, LTD. (IL) | 2017-04-20 | — | — | WO | disclosed |
| US-20160289158-A1 | Amine Salts of a Prostacyclin Analog | CAYMAN CHEMICAL COMPANY INCORPORATED (US) | 2016-10-06 | — | — | US | disclosed |
| US-20150315114-A1 | Methods of Synthesizing a Prostacyclin Analog | CAYMAN CHEMICAL COMPANY INCORPORATED | 2015-11-05 | — | — | US | disclosed |
| US-20120172321-A1 | HSP90 INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-07-05 | — | — | US | disclosed |
| US-8178689-B2 | Tricyclic compounds | HOFFMAN-LA ROCHE INC. (US) | 2012-05-15 | — | — | US | disclosed |
| US-20110313002-A1 | TRICYCLIC COMPOUNDS | SARABU RAMAKANTH (US) | 2011-12-22 | — | — | US | disclosed |
| US-8071766-B2 | HSP90 inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-12-06 | — | — | US | disclosed |
| US-20110053873-A1 | HSP90 INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-03-03 | — | — | US | disclosed |
| US-20100160369-A1 | S1P1 Agonists and Methods of Making And Using | EXELIXIS, INC. (US) | 2010-06-24 | — | — | US | disclosed |
| US-7741327-B2 | Pyrrolidinone glucokinase activators | HOFFMANN-LA ROCHE INC. (US) | 2010-06-22 | — | — | US | disclosed |
| US-20090305998-A1 | HSP90 INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-12-10 | — | — | US | disclosed |
| US-20090264445-A1 | PYRROLIDINONE GLUCOKINASE ACTIVATORS | BERTHEL STEVEN JOSEPH | 2009-10-22 | — | — | US | disclosed |
| EP-2057165-A1 | ACYCLIC AMINE INHIBITORS OF NUCLEOSIDE PHOSPHORYLASES AND HYDROLASES | INDUSTRIAL RESEARCH LIMITED (NZ) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008030119-A1 | ACYCLIC AMINE INHIBITORS OF NUCLEOSIDE PHOSPHORYLASES AND HYDROLASES | INDUSTRIAL RESEARCH LIMITED (NZ) | 2008-03-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160289158-A1 | Amine Salts of a Prostacyclin Analog | PTGIS, PTGIR, PTGER1 | CA2 1199/4885ALDH1A1 519/4885NPSR1 85/4885 |
| US-20090305998-A1 | HSP90 INHIBITORS | HSP90AB1, HSP90AA1, HSP90B1 | CA2 4094/4885ALDH1A1 1601/4885NPSR1 4385/4885 |
| US-20150315114-A1 | Methods of Synthesizing a Prostacyclin Analog | PTGIS, CYP11B2, CYP11B1 | CA2 406/4885ALDH1A1 257/4885NPSR1 2036/4885 |
| US-20170362240-A1 | 4,6-SUBSTITUTED-PYRAZOLO[1,5-a]PYRAZINES AS JANUS KINASE INHIBITORS | JAK1, JAK3, JAK2 | CA2 3437/4885ALDH1A1 1526/4885NPSR1 2228/4885 |
| US-20090264445-A1 | PYRROLIDINONE GLUCOKINASE ACTIVATORS | GCKR, GCK, PDK2 | CA2 2535/4885ALDH1A1 1129/4885NPSR1 3628/4885 |
| US-20180141889-A1 | METHODS OF SYNTHESIZING A PROSTACYCLIN ANALOG | PTGIS, CYP11B1, CYP11B2 | CA2 465/4885ALDH1A1 278/4885NPSR1 2209/4885 |
| US-20180118656-A1 | AMINE SALTS OF A PROSTACYCLIN ANALOG | PTGIS, PTGIR, PTGER1 | CA2 1199/4885ALDH1A1 519/4885NPSR1 85/4885 |
| US-20110053873-A1 | HSP90 INHIBITORS | HSP90AB1, HSP90AA1, HSP90B1 | CA2 4141/4885ALDH1A1 1554/4885NPSR1 4375/4885 |
| US-20170297995-A1 | METHODS OF SYNTHESIZING A PROSTACYCLIN ANALOG | PTGIS, CYP11B2, CYP11B1 | CA2 406/4885ALDH1A1 257/4885NPSR1 2036/4885 |
| US-20120172321-A1 | HSP90 INHIBITORS | HSP90AB1, HSP90AA1, HSP90B1 | CA2 4094/4885ALDH1A1 1601/4885NPSR1 4385/4885 |
| US-20100160369-A1 | S1P1 Agonists and Methods of Making And Using | S1PR1, S1PR5, S1PR3 | CA2 3515/4885ALDH1A1 1246/4885NPSR1 39/4885 |
| US-20110313002-A1 | TRICYCLIC COMPOUNDS | GPR119, PC, GOT2 | CA2 2100/4885ALDH1A1 545/4885NPSR1 1900/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.