Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.40 |
| ▸ | TP53 | P04637 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.39 |
| ▸ | SLC12A5 | Q9H2X9 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.37 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL44557 | 0.90 | KMT2A (0.40) | ALDH1A1SMN1; SMN2TP53MAPTNR3C2 | |
| SCHEMBL45229 | 0.89 | TP53 (0.41) | ALDH1A1SMN1; SMN2TP53MAPTNR3C2 | |
| SCHEMBL44780 | 0.85 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2TP53MAPTLMNA | |
| SCHEMBL44636 | 0.83 | TP53 (0.43) | ALDH1A1SMN1; SMN2TP53MAPTLMNA | |
| SCHEMBL39342 | 0.82 | CYP19A1 (0.53) | ALDH1A1SMN1; SMN2TP53MAPTLMNA | |
| SCHEMBL44302 | 0.81 | SMN1; SMN2 (0.50) | ALDH1A1SMN1; SMN2TP53MAPTLMNA | |
| SCHEMBL39660 | 0.80 | CYP19A1 (0.56) | ALDH1A1TP53MAPTLMNATHRB | |
| SCHEMBL44918 | 0.79 | CYP19A1 (0.44) | ALDH1A1SMN1; SMN2TP53MAPTNR3C2 | |
| SCHEMBL44862 | 0.77 | GAA (0.47) | ALDH1A1SMN1; SMN2TP53MAPTLMNA | |
| SCHEMBL44400 | 0.76 | ALDH1A1 (0.45) | ALDH1A1TP53NR3C2LMNASLC12A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | claimed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |