Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 3/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL44780 | 0.86 | ALDH1A1 (0.44) | CYP19A1MAPTALDH1A1USP2LMNA | |
| SCHEMBL44302 | 0.86 | SMN1; SMN2 (0.50) | CYP19A1NAMPTMAPTALDH1A1USP2 | |
| SCHEMBL44750 | 0.85 | CYP1A2 (0.41) | CYP19A1MAPTALDH1A1USP2LMNA | |
| SCHEMBL39342 | 0.83 | CYP19A1 (0.53) | CYP19A1MAPTALDH1A1USP2LMNA | |
| SCHEMBL39660 | 0.82 | CYP19A1 (0.56) | CYP19A1MAPTALDH1A1LMNAHSD17B1 | |
| SCHEMBL44636 | 0.81 | TP53 (0.43) | CYP19A1MAPTALDH1A1USP2LMNA | |
| SCHEMBL44557 | 0.81 | KMT2A (0.40) | CYP19A1NR3C2MAPTALDH1A1USP2 | |
| SCHEMBL45229 | 0.79 | TP53 (0.41) | CYP19A1NR3C2MAPTALDH1A1USP2 | |
| SCHEMBL44139 | 0.79 | ALDH1A1 (0.43) | CYP19A1NR3C2MAPTALDH1A1USP2 | |
| SCHEMBL44398 | 0.78 | CHRM3 (0.52) | TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | claimed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |