Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 1/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | TDO2 | P48775 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | TNKS | O95271 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4415344 | 1.00 | MIF (0.67) | MIFCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL14926713 | 0.86 | NFE2L2 (0.49) | MIFNFE2L2CYP1A1CYP1B1KLKB1 | |
| SCHEMBL5199344 | 0.86 | MIF (0.53) | MIFCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL5199333 | 0.86 | MIF (0.53) | MIFCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL25733407 | 0.84 | NFE2L2 (0.47) | MIFNFE2L2HDAC3HDAC4HDAC1 | |
| SCHEMBL26316886 | 0.84 | NFE2L2 (0.47) | MIFNFE2L2CYP1A1CYP1B1KLKB1 | |
| SCHEMBL584565 | 0.81 | CYP1A1 (0.55) | MIFCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL30278658 | 0.81 | CYP1A1 (0.55) | MIFCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL584566 | 0.81 | CYP1A1 (0.55) | MIFCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL29407005 | 0.81 | MIF (0.71) | MIFCYP2C19NFE2L2TDO2CYP1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11872202-B2 | Pleuromutilin cinnamic acid ester compounds with activities against antibiotic-resistant infections | SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2024-01-16 | — | — | US | disclosed |
| US-20230172889-A1 | PLEUROMUTILIN CINNAMIC ACID ESTER COMPOUNDS WITH ACTIVITIES AGAINST ANTIBIOTIC-RESISTANT INFECTIONS | SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2023-06-08 | — | — | US | disclosed |
| US-20120077793-A1 | Compounds for the Treatment of Metabolic Disorders | PROSIDION LIMITED (GB) | 2012-03-29 | — | — | US | disclosed |
| WO-2011032050-A2 | GYRASE INHIBITORS | TRIUS THERAPEUTICS, INC. (US) | 2011-03-17 | — | — | WO | disclosed |
| EP-2096109-A1 | CARBOXYLIC ACID DERIVATIVE | Astellas Pharma Inc. (JP) | 2009-09-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230172889-A1 | PLEUROMUTILIN CINNAMIC ACID ESTER COMPOUNDS WITH ACTIVITIES AGAINST ANTIBIOTIC-RESISTANT INFECTIONS | RELA, PLEC, ABL1 | MIF 5/4885CYP3A4 1216/4885CYP2D6 1242/4885 |
| US-20120077793-A1 | Compounds for the Treatment of Metabolic Disorders | GPR119, GPR132, FFAR2 | MIF 4730/4885CYP3A4 2072/4885CYP2D6 1922/4885 |
| US-11872202-B2 | Pleuromutilin cinnamic acid ester compounds with activities against antibiotic-resistant infections | RELA, PLEC, ABL1 | MIF 5/4885CYP3A4 1216/4885CYP2D6 1242/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.