SCHEMBL4415875

SCHEMBL4415875

N#Cc1c(F)c(F)c(CN)c(F)c1F

nearest known ligand 0.30

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
LOXL2 Q9Y4K0 1/20 0.30
TRPV4 Q9HBA0 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4949396 0.95
SCHEMBL7633373 0.88
SCHEMBL10449755 0.79 TRPV4 (0.32) TRPV4
SCHEMBL545418 0.78 LOXL2 (0.33) LOXL2
SCHEMBL57543 0.78 TRPV4 (0.41) TRPV4
SCHEMBL1322700 0.77 MEN1 (0.33) TRPV4
SCHEMBL24146397 0.76 MEN1 (0.31)
SCHEMBL9810572 0.75 POLB (0.30) TRPV4
SCHEMBL11047273 0.75 HPGD (0.38) TRPV4
SCHEMBL31612588 0.74 TRPV4 (0.39) TRPV4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1299343-B1 PRODUCTION METHOD FOR BENZENEDIMETHANOL COMPOUND SHOWA DENKO KK (JP) 2009-01-14 EP disclosed
EP-1506160-B1 PRODUCTION PROCESS OF AMINOMETHYL GROUP-CONTAINING BENZAMIDE COMPOUND SHOWA DENKO KK (JP) 2008-08-13 EP disclosed
CN-100354252-C Production process of aminomethyl group-containing benzamide compound SHOWA DENKO KK (JP) 2007-12-12 CN disclosed
US-7227036-B2 Production process of aminomethyl group-containing benzamide compound SHOWA DENKO K.K. (JP) 2007-06-05 US disclosed
EP-1508567-B1 Process for producing cyanobenzoic acid derivatives SHOWA DENKO KK (JP) 2006-11-15 EP disclosed
EP-1721892-A1 Method for producing cyanophenyl derivatives Showa Denko Kabushiki Kaisha (JP) 2006-11-15 EP disclosed
EP-1721891-A1 Method for producing cyanophenyl derivatives Showa Denko Kabushiki Kaisha (JP) 2006-11-15 EP disclosed
US-20050203313-A1 Production process of aminomethyl group-containing benzamide compound SHOWA DENKO K.K. (JP) 2005-09-15 US disclosed
CN-1656056-A Production process of aminomethyl group-containing benzamide compound SHOWA DENKO KK (JP) 2005-08-17 CN disclosed
US-6909023-B2 Production method for benzenedimethanol compound SHOWA DENKO K.K. (JP) 2005-06-21 US disclosed
EP-1004574-B1 Process for producing cyanobenzyl compounds SHOWA DENKO KK (JP) 2003-03-19 EP disclosed
US-6433211-B1 SELECTIVITY HYDRATION OF AROMATIC DINITRILES SHOWA DENKO KABUSHIKI KAISHA (JP) 2002-08-13 US disclosed
WO-2002002504-A1 PRODUCTION METHOD FOR BENZENEDIMETHANOL COMPOUND SHOWA DENKO K.K. (JP) 2002-01-10 WO disclosed
US-6262292-B1 FORMING CYANAOBENZALDEHYDE BY OXIDATION OF CYANOBENZYLAMINE SHOWA DENKO K.K. (JP) 2001-07-17 US disclosed
EP-1083165-A1 PROCESSES FOR PRODUCING CYANOPHENYL DERIVATIVES Showa Denko Kabushiki Kaisha (JP) 2001-03-14 EP disclosed
US-6187945-B1 TRANSFORMING AN AMINOMETHYL GROUP OF A CYANOBENZYLAMINE COMPOUND INTO A HYDROXYMETHYL GROUP, A HALOMETHYL GROUP, OR AN ACYLOXYMETHYL GROUP BY DIAZOTIZATION AND HYDROXYLATION, HALOGENATION OR ACYLATION SHOWA DENKO K.K. (JP) 2001-02-13 US disclosed
EP-1004574-A1 Process for producing cyanobenzyl compounds Showa Denko Kabushiki Kaisha (JP) 2000-05-31 EP disclosed
EP-0989115-A2 Process for producing cyanobenzoic acid derivatives Showa Denko Kabushiki Kaisha (JP) 2000-03-29 EP disclosed
EP-0099622-B1 PROCESS FOR THE HYDROGENATION OF PERHALOGENATED TEREPHTHALONITRILES TO AMINES, 2,3,5,6-TETRAFLUOROXYLYLENE DIAMINE AND SALTS THEREOF IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1985-12-04 EP disclosed
EP-0099622-A1 Process for the hydrogenation of perhalogenated terephthalonitriles to amines, 2,3,5,6-tetrafluoroxylylene diamine and salts thereof IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1984-02-01 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050203313-A1 Production process of aminomethyl group-containing benzamide compound BCAT2, BCAT1, KCNH1 LOXL2 1988/4885TRPV4 3368/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.