Sugi Predict

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SCHEMBL4415911

SCHEMBL4415911

Fc1cc(NCC2C3CN(Cc4ccc(Cl)c(Cl)c4)CC23)ccc1N1CCOCC1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 7/20 0.40
▸ ALDH1A1 P00352 6/20 0.40
▸ HTT P42858 6/20 0.40
▸ GAA P10253 4/20 0.40
▸ TSHR P16473 3/20 0.40
▸ KDM4E B2RXH2 2/20 0.40
▸ MAPT P10636 6/20 0.39
▸ NPC1 O15118 4/20 0.39
▸ RAB9A P51151 4/20 0.39
▸ SMN1; SMN2 Q16637 4/20 0.39
▸ L3MBTL1 Q9Y468 2/20 0.39
▸ USP30 Q70CQ3 1/20 0.38
▸ ALOX15 P16050 1/20 0.38
▸ HSD17B10 Q99714 1/20 0.38
▸ HPGD P15428 3/20 0.38
▸ KMT2A Q03164 3/20 0.38
▸ MEN1 O00255 2/20 0.38
▸ MCOLN3 Q8TDD5 1/20 0.38
▸ TP53 P04637 1/20 0.38
▸ POLB P06746 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4552124 0.92 P2RX3 (0.43) LMNAALDH1A1HTTGAATSHR
SCHEMBL4413699 0.91 GAA (0.48) LMNAALDH1A1HTTGAAMAPT
SCHEMBL4412370 0.91 L3MBTL1 (0.44) LMNAHTTGAAMAPTNPC1
SCHEMBL2170676 0.89 LMNA (0.44) LMNAALDH1A1HTTGAAMAPT
SCHEMBL4417596 0.89 GAA (0.42) LMNAALDH1A1HTTGAATSHR
SCHEMBL4412123 0.89 L3MBTL1 (0.41) LMNAALDH1A1HTTGAAMAPT
SCHEMBL4419284 0.89 NPC1 (0.43) LMNAALDH1A1HTTGAATSHR
SCHEMBL4419245 0.89 NPC1 (0.46) LMNAALDH1A1HTTGAATSHR
SCHEMBL4418856 0.89 ALDH1A1 (0.45) LMNAALDH1A1GAAKDM4EMAPT
SCHEMBL4414914 0.88 HIF1A (0.47) LMNAALDH1A1HTTGAATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1680124-B1 BICYCLIC [3.1.0] DERIVATIVES AS GLYCINE TRANSPORTER INHIBITORS PFIZER PROD INC (US) 2017-05-31 — — EP claimed
EP-1680124-A4 BICYCLIC [3.1.0] DERIVATIVES AS GLYCINE TRANSPORTER INHIBITORS PFIZER PROD INC (US) 2009-05-13 — — EP claimed
JP-2007508374-A — — 2007-04-05 — — JP claimed
EP-1680124-A2 BICYCLIC [3.1.0] DERIVATIVES AS GLYCINE TRANSPORTER INHIBITORS Pfizer Products Incorporated (US) 2006-07-19 — — EP claimed
US-20050096375-A1 Bicyclic [3.1.0] derivatives as glycine transporter inhibitors PFIZER INC. 2005-05-05 — — US claimed
WO-2005037216-A2 BICYCLIC [3.1.0] DERIVATIVES AS GLYCINE TRANSPORTER INHIBITORS PFIZER PRODUCTS INC. (US) 2005-04-28 — — WO claimed
EP-1680124-B1 BICYCLIC [3.1.0] DERIVATIVES AS GLYCINE TRANSPORTER INHIBITORS PFIZER PROD INC (US) 2017-05-31 — — EP disclosed
US-7473787-B2 Bicyclic [3.1.0] derivatives as glycine transporter inhibitors PFIZER INC (US) 2009-01-06 — — US disclosed
US-20050096375-A1 Bicyclic [3.1.0] derivatives as glycine transporter inhibitors PFIZER INC. 2005-05-05 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050096375-A1 Bicyclic [3.1.0] derivatives as glycine transporter inhibitors SLC6A5, SLC1A5, SLC6A3 LMNA 4565/4885ALDH1A1 3166/4885HTT 1090/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.