Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR2 | O15552 | 1/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
| ▸ | XIAP | P98170 | 1/20 | 0.30 |
| ▸ | CCR2 | P41597 | 2/20 | 0.30 |
| ▸ | CCR5 | P51681 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4424128 | 0.88 | CCR2 (0.35) | CCR2CCR5 | |
| SCHEMBL5032000 | 0.88 | CCR2 (0.38) | CCR2CCR5 | |
| SCHEMBL4421314 | 0.85 | CCR2 (0.38) | CCR2CCR5 | |
| SCHEMBL4424140 | 0.85 | IRAK4 (0.41) | CCR2 | |
| SCHEMBL4551359 | 0.85 | NSD2 (0.47) | — | |
| SCHEMBL4417401 | 0.85 | IRAK4 (0.39) | CCR2CCR5 | |
| SCHEMBL4426067 | 0.85 | CNR1 (0.40) | CCR2CCR5 | |
| SCHEMBL4422907 | 0.83 | PIK3CD (0.44) | — | |
| SCHEMBL4418746 | 0.83 | CCR2 (0.49) | CCR2CCR5 | |
| SCHEMBL4417546 | 0.81 | CCR2 (0.32) | CCR2CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1606255-B1 | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL MYERS SQUIBB CO (US) | 2009-11-11 | — | — | EP | claimed |