Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | BRAF | P15056 | 3/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SCARB1 | Q8WTV0 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4416963 | 0.90 | MAPK14 (0.44) | BRAFMAPK14MEN1KMT2ALMNA | |
| SCHEMBL4417785 | 0.88 | MAPK14 (0.43) | SMN1; SMN2BRAFMAPK14MEN1KMT2A | |
| SCHEMBL5494587 | 0.84 | MAPK14 (0.42) | BRAFMAPK14 | |
| SCHEMBL4417851 | 0.83 | MAPK14 (0.44) | SMN1; SMN2MAPK14RAB9AMEN1KMT2A | |
| SCHEMBL4416273 | 0.82 | MAPK14 (0.41) | MAPK14MAPTSCARB1 | |
| SCHEMBL5490019 | 0.81 | RAB9A (0.42) | SMN1; SMN2MAPK14RAB9AMEN1KMT2A | |
| SCHEMBL4726185 | 0.80 | BRAF (0.42) | BRAFMAPK14SCARB1 | |
| SCHEMBL4408299 | 0.80 | MAPK14 (0.42) | MAPK14SCARB1 | |
| SCHEMBL5497982 | 0.75 | MAPK14 (0.52) | BRAFMAPK14SCARB1 | |
| SCHEMBL14534449 | 0.74 | LMNA (0.46) | SMN1; SMN2RAB9AMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007056016-A2 | BISAMIDE CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-05-18 | — | — | WO | disclosed |