Water

Water

SCHEMBL4421329

CCOC(=O)NC=CC(=O)O.O

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 6/20 0.50
GAA P10253 3/20 0.38
MGAM O43451 1/20 0.38
SI P14410 1/20 0.38
MGAM2 Q2M2H8 1/20 0.38
ALDH1A1 P00352 5/20 0.36
RAB9A P51151 2/20 0.36
CYP2D6 P10635 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
POLB P06746 1/20 0.35
LMNA P02545 1/20 0.34
HSD17B10 Q99714 1/20 0.34
MAPT P10636 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
ALOX15 P16050 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Water SCHEMBL8356208 1.00 HCAR2 (0.50) HCAR2GAAMGAMSIMGAM2
SCHEMBL132383 0.98 HCAR2 (0.52) HCAR2GAAMGAMSIMGAM2
SCHEMBL19612450 0.96 HCAR2 (0.50) HCAR2GAAMGAMSIMGAM2
Hydroxyamine SCHEMBL7066541 0.94 HCAR2 (0.48) HCAR2GAAMGAMSIMGAM2
Urea SCHEMBL11584414 0.92 HCAR2 (0.47) HCAR2GAAMGAMSIMGAM2
SCHEMBL11648494 0.92 HCAR2 (0.47) HCAR2GAAMGAMSIMGAM2
Acrylic Acid SCHEMBL4558161 0.91 HCAR2 (0.46) HCAR2GAAMGAMSIMGAM2
SCHEMBL8519773 0.89 HCAR2 (0.44) HCAR2GAAMGAMSIMGAM2
Urethane SCHEMBL5604647 0.89 ALOX15 (0.52) HCAR2GAAMGAMSIMGAM2
SCHEMBL5690799 0.85

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3046778-B1 THERMO TRANSFER FILMS FOR THE DRY LACQUERING OF SURFACES BASF SE (DE) 2017-12-20 EP claimed
EP-0135971-B1 METHOD OF OPTICALLY CONNECTING A LIGHT CONDUCTOR TO AN ELECTRO-OPTICAL DEVICE Koninklijke Philips Electronics N.V. (NL) 1988-07-27 EP claimed
EP-0135971-A2 Method of optically connecting a light conductor to an electro-optical device Koninklijke Philips Electronics N.V. (NL) 1985-04-03 EP claimed
EP-0130680-A2 Cure to elastomers composition LOCTITE CORPORATION (US) 1985-01-09 EP claimed
US-4439600-A Cure to elastomers compositions LOCTITE CORPORATION (US) 1984-03-27 US claimed
US-11952453-B2 Radiation curable compositions for coating optical fiber and the coatings produced therefrom COVESTRO (NETHERLANDS) B.V (NL) 2024-04-09 US disclosed
CN-117338303-B Temperature-control viscosity multichannel hydrogel electrode for intra-operative intracranial electroencephalogram monitoring 华中科技大学 2024-03-26 CN disclosed
CN-112512488-B External gel preparation for skin 株式会社资生堂 2024-02-02 CN disclosed
CN-117338303-A Temperature-control viscosity multichannel hydrogel electrode for intra-operative intracranial electroencephalogram monitoring 华中科技大学 2024-01-05 CN disclosed
CN-112573838-B Optical fiber article and its production and use 肖特股份有限公司 2023-12-26 CN disclosed
US-11256028-B2 Thermally resistant radiation curable coatings for optical fiber COVESTRO (NETHERLANDS) B.V. (NL) 2022-02-22 US disclosed
US-20220017773-A1 FILLED RADIATION CURABLE COMPOSITIONS FOR COATING OPTICAL FIBER AND THE COATINGS PRODUCED THEREFROM COVESTRO (NETHERLANDS) B.V. (NL) 2022-01-20 US disclosed
WO-2020114902-A1 FILLED RADIATION CURABLE COMPOSITIONS FOR COATING OPTICAL FIBER AND THE COATINGS PRODUCED THEREFROM DSM IP ASSETS B.V. (NL) 2020-06-11 WO disclosed
US-20200166700-A1 THERMALLY RESISTANT RADIATION CURABLE COATINGS FOR OPTICAL FIBER COVESTRO (NETHERLANDS) B.V. (NL) 2020-05-28 US disclosed
EP-3630693-A1 THERMALLY RESISTANT RADIATION CURABLE COATINGS FOR OPTICAL FIBER DSM IP Assets B.V. (NL) 2020-04-08 EP disclosed
WO-2018220605-A1 THERMALLY RESISTANT RADIATION CURABLE COATINGS FOR OPTICAL FIBER DSM IP ASSETS BV (NL) 2018-12-06 WO disclosed
WO-2009150585-A1 MICRO-FLUIDIC SYSTEMS BASED ON ACTUATOR ELEMENTS KONINKLIJKE PHILIPS ELECTRONICS N.V. (NL) 2009-12-17 WO disclosed
EP-0135971-B1 METHOD OF OPTICALLY CONNECTING A LIGHT CONDUCTOR TO AN ELECTRO-OPTICAL DEVICE Koninklijke Philips Electronics N.V. (NL) 1988-07-27 EP disclosed
EP-0135971-A2 Method of optically connecting a light conductor to an electro-optical device Koninklijke Philips Electronics N.V. (NL) 1985-04-03 EP disclosed
EP-0135971-A2 Method of optically connecting a light conductor to an electro-optical device Koninklijke Philips Electronics N.V. (NL) 1985-04-03 EP disclosed