Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.49 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TNKS | O95271 | 1/20 | 0.46 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.46 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.46 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.46 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.46 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.46 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.46 |
| ▸ | NAAA | Q02083 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9205693 | 0.89 | WDR5 (0.70) | WDR5POLBADRB2ADRB1ADRB3 | |
| SCHEMBL9321543 | 0.85 | MAOA (0.49) | WDR5POLBKDM4EALDH1A1MAOB | |
| SCHEMBL1812614 | 0.82 | SMN1; SMN2 (0.65) | POLBKDM4EALDH1A1MAOBAOC3 | |
| SCHEMBL2170915 | 0.79 | FFAR1 (0.58) | ADRB3ALDH1A1TNKSPARP15PARP14 | |
| SCHEMBL1816835 | 0.78 | SMN1; SMN2 (0.58) | POLBALDH1A1SMN1; SMN2 | |
| SCHEMBL10715309 | 0.78 | MAPT (0.54) | WDR5ALDH1A1MAOBSMN1; SMN2NAAA | |
| SCHEMBL10876902 | 0.76 | ALDH1A1 (0.53) | WDR5ADRB2ADRB1ADRB3KDM4E | |
| SCHEMBL8966908 | 0.76 | LTA4H (0.66) | WDR5MAOBSMN1; SMN2FFAR1 | |
| SCHEMBL10506137 | 0.76 | MEN1 (0.58) | POLBKDM4EALDH1A1PARP10 | |
| SCHEMBL7751869 | 0.76 | SCN5A (0.45) | WDR5ALDH1A1MAOBSMN1; SMN2NAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761480-B1 | MAO-B INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-02-18 | — | — | EP | claimed |
| EP-1761480-B1 | MAO-B INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-02-18 | — | — | EP | disclosed |