Sugi Predict

Sugi Predict / Compounds / SCHEMBL442759

SCHEMBL442759

SCHEMBL442759

Nc1n[c]nc2[nH]cnc12

nearest known ligand 0.33

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ PNP P00491 1/20 0.32
▸ PI4KA P42356 2/20 0.31
▸ PI4K2B Q8TCG2 2/20 0.31
▸ PI4K2A Q9BTU6 2/20 0.31
▸ PI4KB Q9UBF8 2/20 0.31
▸ GDA Q9Y2T3 2/20 0.31
▸ LMNA P02545 1/20 0.31
▸ DRD3 P35462 1/20 0.31
▸ XDH P47989 1/20 0.31
▸ LRRK2 Q5S007 1/20 0.31
▸ BTK Q06187 1/20 0.31
▸ PARP1 P09874 1/20 0.31
▸ PDPK1 O15530 1/20 0.31
▸ PRKCI P41743 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8169178 0.75 BCL2 (0.34) LMNA
SCHEMBL3444335 0.75 CSNK2A1 (0.34) LRRK2BTKPARP1
SCHEMBL9426162 0.75 — —
SCHEMBL2139275 0.75 PDPK1 (0.35) PARP1PDPK1
SCHEMBL546074 0.72 XDH (0.35) XDHPDPK1
Adenine SCHEMBL3416954 0.71 PI4KA (0.48) PNPPI4KAPI4K2BPI4K2API4KB
Adenine SCHEMBL3414603 0.71 PI4KA (0.48) PNPPI4KAPI4K2BPI4K2API4KB
Adenine SCHEMBL8110 0.71 PI4KA (0.48) PNPPI4KAPI4K2BPI4K2API4KB
Adenine SCHEMBL3413247 0.71 PI4KA (0.48) PNPPI4KAPI4K2BPI4K2API4KB
SCHEMBL545951 0.71 PDPK1 (0.37) LRRK2PDPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 646 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12037328-B2 Compounds containing benzo[d][1,3]oxathiole, benzo[d][1,3]oxathiole 3-oxide or benzo[d][1,3]oxathiole 3,3-dioxide and methods/uses thereof as agonists of G protein-coupled receptor 119 PRAMANA PHARMACEUTICALS INC. (CA) 2024-07-16 — — US disclosed
US-12029728-B2 Small molecules with anti-protozoan activity NEW MEXICO TECH UNIVERSITY RESEARCH PARK CORPORATION (US) 2024-07-09 — — US disclosed
US-12029731-B2 Acyl benzo[d]thiazol-2-amine and their methods of use BIOHAVEN THERAPEUTICS LTD. (US) 2024-07-09 — — US disclosed
WO-2024135721-A1 METHOD FOR PRODUCING PRODUCTION INTERMEDIATE, PRODUCTION INTERMEDIATE THEREOF, AND METHOD FOR PRODUCING CROSSLINKED ARTIFICIAL NUCLEIC ACID INTERMEDIATE BY USING SAME 田辺三菱製薬株式会社 2024-06-27 — — WO disclosed
EP-4380566-A1 METHODS OF TREATING MIGRAINE WITH MNK INHIBITORS 4E Therapeutics, Inc. (US) 2024-06-12 — — EP disclosed
US-12005047-B2 Riluzole prodrugs and their use BIOHAVEN THERAPEUTICS LTD. (US) 2024-06-11 — — US disclosed
US-12005046-B2 Riluzole prodrugs and their use BIOHAVEN THERAPEUTICS LTD. (US) 2024-06-11 — — US disclosed
CN-118119389-A Prodrugs and derivatives of des-phosphate nupharicin and uses thereof 人类生物科学股份有限公司 2024-05-31 — — CN disclosed
CN-118076583-A Methods and compositions for treating cancer 安可诺瓦治疗公司 2024-05-24 — — CN disclosed
CN-118076354-A Methods of treating migraine with MNK inhibitors 4E治疗公司 2024-05-24 — — CN disclosed
EP-0916674-A1 Purine derivatives having cyclopropane ring SUMIKA FINE CHEMICALS Co., Ltd. (JP) 1999-05-19 — — EP disclosed
US-5849482-A Crosslinking oligonucleotides EPOCH PHARMACEUTICALS, INC. (US) 1998-12-15 — — US disclosed
EP-0842186-A1 CROSS-LINKING OLIGONUCLEOTIDES MICROPROBE CORPORATION (US) 1998-05-20 — — EP disclosed
EP-0815853-A2 Sustained-release preparation for bioactive substance having an acidic group TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-01-07 — — EP disclosed
EP-0766683-A1 NOVEL SUBSTITUTED PURINYL DERIVATIVES WITH IMMUNOMODULATING ACTIVITY BIOCHEM PHARMA INC (CA) 1997-04-09 — — EP disclosed
WO-1996040711-A1 CROSS-LINKING OLIGONUCLEOTIDES MICROPROBE CORPORATION (US) 1996-12-19 — — WO disclosed
WO-1995035297-A1 NOVEL SUBSTITUTED PURINYL DERIVATIVES WITH IMMUNOMODULATING ACTIVITY BIOCHEM PHARMA INC. (CA) 1995-12-28 — — WO disclosed
US-4704392-A VIRICIDES SYNTEX (U.S.A.) INC. (US) 1987-11-03 — — US disclosed
US-4605659-A HERPES; HEPATITUS SYNTEX (U.S.A.) INC. (US) 1986-08-12 — — US disclosed
US-4578460-A N-6-aminopurinyl-4-hydroxy-2-methyl-2H-1,2-benxothiazine-3-carboxamide 1,1-dioxide compound FRANCIA FARMACEUTICI S.R.L. (IT) 1986-03-25 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12005046-B2 Riluzole prodrugs and their use APEH, ALDH1A2, UGT1A9 PNP 534/4885PI4KA 4409/4885PI4K2B 4442/4885
US-12029731-B2 Acyl benzo[d]thiazol-2-amine and their methods of use BRCA1, ABAT, HDAC1 PNP 3633/4885PI4KA 4617/4885PI4K2B 4678/4885
US-12005047-B2 Riluzole prodrugs and their use APEH, ALDH1A2, UGT1A9 PNP 534/4885PI4KA 4409/4885PI4K2B 4442/4885
US-12037328-B2 Compounds containing benzo[d][1,3]oxathiole, benzo[d][1,3]oxathiole 3-oxide or benzo[d][1,3]oxathiole 3,3-dioxide and methods/uses thereof as agonists of G protein-coupled receptor 119 GPR119, GPR3, GPR39 PNP 3221/4885PI4KA 2274/4885PI4K2B 1869/4885
US-12029728-B2 Small molecules with anti-protozoan activity GBA3, CTSA, ITPA PNP 663/4885PI4KA 1702/4885PI4K2B 2529/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.