Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 2/20 | 0.42 |
| ▸ | ITGAV | P06756 | 2/20 | 0.42 |
| ▸ | ITGB5 | P18084 | 2/20 | 0.42 |
| ▸ | ITGB6 | P18564 | 2/20 | 0.42 |
| ▸ | FPR1 | P21462 | 2/20 | 0.38 |
| ▸ | ITGB8 | P26012 | 1/20 | 0.38 |
| ▸ | TRPC5 | Q9UL62 | 2/20 | 0.38 |
| ▸ | CETP | P11597 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 2/20 | 0.37 |
| ▸ | WDR5 | P61964 | 1/20 | 0.37 |
| ▸ | MMP12 | P39900 | 1/20 | 0.36 |
| ▸ | GLS | O94925 | 3/20 | 0.35 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4431717 | 0.93 | MMP12 (0.40) | ITGB3ITGAVITGB5ITGB6FPR1 | |
| SCHEMBL4436912 | 0.91 | SMN1; SMN2 (0.40) | FPR1CASP1 | |
| SCHEMBL4426307 | 0.91 | CASP1 (0.39) | FPR1CASP1 | |
| SCHEMBL4434290 | 0.91 | FPR1 (0.39) | FPR1CASP1FFAR1 | |
| SCHEMBL4436745 | 0.90 | SMN1; SMN2 (0.41) | FPR1CASP1 | |
| SCHEMBL4434286 | 0.90 | CTSA (0.39) | ITGB3ITGAVITGB5ITGB6FPR1 | |
| SCHEMBL7429087 | 0.90 | MMP2 (0.38) | FPR1CASP1 | |
| SCHEMBL4427187 | 0.90 | MMP2 (0.38) | FPR1CASP1 | |
| SCHEMBL4429149 | 0.89 | CYP26A1 (0.39) | ITGB3ITGAVITGB5ITGB6FPR1 | |
| SCHEMBL4424644 | 0.89 | FPR1 (0.37) | FPR1CASP1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1213288-B1 | Propanoic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2009-01-14 | — | — | EP | disclosed |
| EP-1213288-A1 | Propanoic acid derivatives that inhibit the binding of integrins to their receptors | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2002-06-12 | — | — | EP | disclosed |