Edetic Acid

Edetic Acid

SCHEMBL44287

O=C([O-])CN(CCN(CC(=O)[O-])CC(=O)[O-])CC(=O)[O-].O=C([O-])CN(CCN(CC(=O)[O-])CC(=O)[O-])CC(=O)[O-].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]

nearest known ligand 0.76

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Edetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACE known ✓ P12821 1/20 0.50
CA4 known ✓ P22748 8/20 0.42
CA2 known ✓ P00918 4/20 0.36
CA1 known ✓ P00915 4/20 0.36
KDM4E B2RXH2 2/20 0.76
ALOX15 P16050 2/20 0.76
MAPT P10636 1/20 0.76
SMN1; SMN2 Q16637 1/20 0.76
TDP1 Q9NUW8 2/20 0.50
EYA2 O00167 1/20 0.50
APP P05067 1/20 0.50
BLM P54132 2/20 0.48
PMP22 Q01453 2/20 0.48
LMNA P02545 1/20 0.48
CHRM2 P08172 1/20 0.48
ADRA2A P08913 1/20 0.48
TSHR P16473 1/20 0.48
DRD1 P21728 1/20 0.48
SLC6A2 P23975 1/20 0.48
SLC6A4 P31645 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Edetic Acid SCHEMBL42427 1.00 KDM4E (0.76) KDM4EALOX15MAPTSMN1; SMN2TDP1
Edetic Acid SCHEMBL906 1.00 KDM4E (0.76) KDM4EALOX15MAPTSMN1; SMN2TDP1
Edetic Acid SCHEMBL3835316 1.00 KDM4E (0.76) KDM4EALOX15MAPTSMN1; SMN2TDP1
Edetic Acid SCHEMBL8376400 0.97 KDM4E (0.73) KDM4EALOX15MAPTSMN1; SMN2TDP1
Edetic Acid SCHEMBL1714086 0.97 KDM4E (0.73) KDM4EALOX15MAPTSMN1; SMN2TDP1
Edetic Acid SCHEMBL2935483 0.97 KDM4E (0.73) KDM4EALOX15MAPTSMN1; SMN2TDP1
Edetic Acid SCHEMBL1090576 0.97 KDM4E (0.73) KDM4EALOX15MAPTSMN1; SMN2TDP1
Edetic Acid SCHEMBL5485760 0.97 KDM4E (0.73) KDM4EALOX15MAPTSMN1; SMN2TDP1
Edetic Acid SCHEMBL16291097 0.97 KDM4E (0.73) KDM4EALOX15MAPTSMN1; SMN2TDP1
Edetic Acid SCHEMBL7190674 0.97 KDM4E (0.73) KDM4EALOX15MAPTSMN1; SMN2TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2062467-B1 ARTICLE WITH A COATING OF ELECTRICALLY CONDUCTIVE POLYMER AND PRECIOUS/SEMIPRECIOUS METAL AND PROCESS FOR PRODUCTION THEREOF ENTHONE (US) 2012-02-15 EP claimed
EP-1553053-B2 The use of calcium carbonate in an acidic aqueous medium MINERALS TECH INC (US) 2011-05-04 EP claimed
EP-2316861-A1 Nitrile rubbers LANXESS Deutschland GmbH (DE) 2011-05-04 EP claimed
EP-2316860-A1 Nitrile rubbers LANXESS Deutschland GmbH (DE) 2011-05-04 EP claimed
US-20240001485-A1 A LASER ETCHING METHOD FOR MEMS PROBES MAXONE SEMICONDUCTOR CO., LTD. (CN) 2024-01-04 US disclosed
US-8153271-B2 Article with a coating of electrically conductive polymer and precious/semiprecious metal and process for production thereof ORMECON GMBH (DE) 2012-04-10 US disclosed
US-8129338-B2 Nitric oxide-blocked cross-linked tetrameric hemoglobin IKOR, INC. (US) 2012-03-06 US disclosed
US-20120039905-A1 The Role of p110 delta Signaling in Morbidity and Lung Pathology Induced by Influenza Virus Infection THE BABRAHAM INSTITUTE 2012-02-16 US disclosed
EP-2062467-B1 ARTICLE WITH A COATING OF ELECTRICALLY CONDUCTIVE POLYMER AND PRECIOUS/SEMIPRECIOUS METAL AND PROCESS FOR PRODUCTION THEREOF ENTHONE (US) 2012-02-15 EP disclosed
US-20120027742-A1 METHODS FOR TREATING ADULT RESPIRATORY DISTRESS SYNDROME COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2012-02-02 US disclosed
US-20110281292-A1 Compositions and methods for identifying antigens which elicit an immune response CHEN SI-YI (US) 2011-11-17 US disclosed
US-20110257080-A1 Hepatitis B Virus Compositions and Methods of Use FOX CHASE CANCER CENTER 2011-10-20 US disclosed
EP-2316423-A1 Parenteral formulations of dopamine agonists VeroScience LLC (US) 2011-05-04 EP disclosed
EP-2316861-A1 Nitrile rubbers LANXESS Deutschland GmbH (DE) 2011-05-04 EP disclosed
WO-2011038002-A1 IMMUNOGENIC EPITOPES AS TARGETS FOR UNIVERSAL CANCER VACCINES YALE UNIVERSITY (US) 2011-03-31 WO disclosed
EP-2299812-A1 TARGETING TGF- AS A THERAPY FOR ALZHEIMER'S DISEASE Yale University (US) 2011-03-30 EP disclosed
US-7868158-B2 Modulation of cytokine signaling regulators and applications for immunotherapy BAYLOR COLLEGE OF MEDICINE (US) 2011-01-11 US disclosed
US-7868159-B2 Modulation of negative immune regulators and applications for immunotherapy BAYLOR COLLEGE OF MEDICINE (US) 2011-01-11 US disclosed
WO-2007038524-A2 COCRYSTALLIZATION METHODS SSCI, INC. (US) 2007-04-05 WO disclosed
US-5919291-A LIQUID EXTRACTED FROM AT LEAST ONE TYPE OF MALVACEAE, ORCHIDACEAE AND ALOE IS USED AS THE WATER-SOLUBLE FUNGUSPROOFING AGENT. MINOLTA CO., LTD. (JP) 1999-07-06 US disclosed