Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GSTP1 | P09211 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.38 |
| ▸ | KIFC1 | Q9BW19 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL44368 | 0.88 | SMN1; SMN2 (0.43) | SMN1; SMN2TP53KMT2AFFAR1MAPT | |
| SCHEMBL44571 | 0.86 | NOTUM (0.47) | SMN1; SMN2TP53KMT2AMAPTTHRB | |
| SCHEMBL44333 | 0.80 | L3MBTL1 (0.58) | SMN1; SMN2TP53KIFC1MAPTTHRB | |
| SCHEMBL44656 | 0.79 | MAPT (0.41) | KMT2AMAPTTHRB | |
| SCHEMBL43903 | 0.78 | KMT2A (0.39) | KCNH2SMN1; SMN2TP53GSTP1KMT2A | |
| SCHEMBL44745 | 0.76 | HDAC6 (0.41) | CYP19A1 | |
| SCHEMBL44391 | 0.75 | THRB (0.44) | KMT2AMAPTTHRB | |
| SCHEMBL19012092 | 0.74 | ACLY (0.47) | SMN1; SMN2TP53GSTP1KMT2AFFAR1 | |
| SCHEMBL24922866 | 0.68 | SIRT2 (0.47) | SMN1; SMN2GSTP1FFAR1SIRT2MAPT | |
| SCHEMBL3667489 | 0.68 | F2RL3 (0.54) | SMN1; SMN2TP53KMT2AMAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | claimed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |