Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL44368 | 0.87 | SMN1; SMN2 (0.43) | SMN1; SMN2L3MBTL1TP53THRBRAB9A | |
| SCHEMBL44399 | 0.86 | KCNH2 (0.40) | CYP19A1SMN1; SMN2TP53THRBMAPK1 | |
| SCHEMBL44333 | 0.85 | L3MBTL1 (0.58) | CYP19A1SMN1; SMN2L3MBTL1TP53THRB | |
| SCHEMBL44656 | 0.81 | MAPT (0.41) | THRBRAB9AKMT2ATSHRMEN1 | |
| SCHEMBL44745 | 0.80 | HDAC6 (0.41) | CYP19A1L3MBTL1 | |
| SCHEMBL44391 | 0.78 | THRB (0.44) | THRBKMT2ATSHRMAPT | |
| SCHEMBL43747 | 0.76 | NOTUM (0.53) | NOTUMSMN1; SMN2TP53RAB9ANPC1 | |
| SCHEMBL96696 | 0.73 | RAB9A (0.68) | NOTUMSMN1; SMN2L3MBTL1TP53THRB | |
| SCHEMBL3667489 | 0.72 | F2RL3 (0.54) | CYP19A1SMN1; SMN2TP53THRBRAB9A | |
| SCHEMBL44365 | 0.72 | NOTUM (0.50) | NOTUMSMN1; SMN2L3MBTL1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | claimed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |