Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YEATS4 | O95619 | 1/20 | 0.61 |
| ▸ | MLLT3 | P42568 | 1/20 | 0.61 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.61 |
| ▸ | YEATS2 | Q9ULM3 | 1/20 | 0.61 |
| ▸ | PLD1 | Q13393 | 8/20 | 0.51 |
| ▸ | PLD2 | O14939 | 7/20 | 0.51 |
| ▸ | CTSS | P25774 | 4/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.47 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5000724 | 0.85 | YEATS4 (0.64) | YEATS4MLLT3MLLT1KCNH2YEATS2 | |
| SCHEMBL4438943 | 0.85 | YEATS4 (0.61) | YEATS4MLLT3MLLT1KCNH2YEATS2 | |
| SCHEMBL4436328 | 0.84 | PLD1 (0.51) | YEATS4MLLT3MLLT1KCNH2YEATS2 | |
| SCHEMBL5000609 | 0.78 | YEATS4 (0.68) | YEATS4MLLT3MLLT1KCNH2YEATS2 | |
| SCHEMBL4444405 | 0.77 | YEATS4 (0.84) | YEATS4MLLT3MLLT1KCNH2YEATS2 | |
| SCHEMBL4438759 | 0.76 | YEATS4 (0.67) | YEATS4MLLT3MLLT1KCNH2YEATS2 | |
| SCHEMBL4440184 | 0.76 | CTSS (0.44) | PLD1PLD2CTSSHTR1AADRA2A | |
| SCHEMBL4446497 | 0.76 | YEATS4 (1.00) | YEATS4MLLT3MLLT1KCNH2YEATS2 | |
| SCHEMBL4433067 | 0.75 | YEATS4 (0.83) | YEATS4MLLT3MLLT1KCNH2YEATS2 | |
| SCHEMBL14349463 | 0.75 | DRD2 (0.70) | YEATS4MLLT3MLLT1KCNH2YEATS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121656-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | Pfizer Products Inc. (US) | 2009-11-25 | — | — | EP | claimed |
| US-20080287479-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | PFIZER INC | 2008-11-20 | — | — | US | claimed |
| WO-2008084300-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | PFIZER PRODUCTS INC. (US) | 2008-07-17 | — | — | WO | claimed |
| US-20150148387-A1 | METHODS OF TREATMENT, DIAGNOSIS AND MONITORING FOR METHAMPHETAMINE TOXICITY WHICH TARGET CERAMIDE METABOLIC PATHWAYS AND CELLULAR SENESCENCE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2015-05-28 | — | — | US | disclosed |
| EP-2121656-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | Pfizer Products Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| US-20080287479-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | PFIZER INC | 2008-11-20 | — | — | US | disclosed |
| US-20080287479-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | PFIZER INC | 2008-11-20 | — | — | US | disclosed |
| WO-2008084300-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | PFIZER PRODUCTS INC. (US) | 2008-07-17 | — | — | WO | disclosed |
| WO-2008084300-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | PFIZER PRODUCTS INC. (US) | 2008-07-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287479-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | SPTLC1, SPTLC2, CPT1A | YEATS4 1467/4885MLLT3 4292/4885MLLT1 1888/4885 |
| US-20150148387-A1 | METHODS OF TREATMENT, DIAGNOSIS AND MONITORING FOR METHAMPHETAMINE TOXICITY WHICH TARGET CERAMIDE METABOLIC PATHWAYS AND CELLULAR SENESCENCE | CERS2, CHKB, CES2 | YEATS4 3165/4885MLLT3 3669/4885MLLT1 2412/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.