Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.58 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.48 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1835163 | 0.83 | ADRB1 (0.51) | — | |
| SCHEMBL27576745 | 0.78 | LMNA (0.66) | ALOX5FFAR1LMNAL3MBTL1 | |
| SCHEMBL4310328 | 0.77 | ALOX5 (0.45) | ALOX5PARP10FFAR1L3MBTL1NR4A1 | |
| SCHEMBL2116330 | 0.76 | ADRB1 (0.76) | — | |
| SCHEMBL28857417 | 0.75 | ALOX5 (0.53) | ALOX5MAOBFFAR1LMNAL3MBTL1 | |
| SCHEMBL4435918 | 0.75 | ALOX5 (0.53) | ALOX5MAOBFFAR1LMNAL3MBTL1 | |
| SCHEMBL2170633 | 0.75 | ALOX5 (0.67) | ALOX5PARP10MAOBNR4A1NR4A2 | |
| SCHEMBL25108838 | 0.75 | BCHE (0.57) | ALOX5MAOBLMNAL3MBTL1 | |
| SCHEMBL585575 | 0.75 | ADRB1 (0.49) | — | |
| SCHEMBL8933773 | 0.74 | ALOX5 (1.00) | ALOX5PARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761480-B1 | MAO-B INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-02-18 | — | — | EP | claimed |
| EP-1761480-B1 | MAO-B INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-02-18 | — | — | EP | disclosed |