Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | CNR2 | P34972 | 7/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5559678 | 0.82 | CNR2 (0.50) | ALDH1A1KDM4ELMNACNR2MAPT | |
| SCHEMBL5010343 | 0.80 | CSNK1D (0.67) | HTTALDH1A1KDM4ELMNAHPGD | |
| SCHEMBL4438731 | 0.79 | ALDH1A1 (0.44) | HTTALDH1A1KDM4ELMNAHPGD | |
| SCHEMBL11354056 | 0.76 | KDM4E (0.54) | HTTALDH1A1KDM4ELMNAHPGD | |
| SCHEMBL1753075 | 0.75 | CSNK1D (0.60) | HTTALDH1A1KDM4ELMNAHPGD | |
| SCHEMBL1752929 | 0.73 | MAPT (0.50) | HTTALDH1A1KDM4ELMNAHPGD | |
| SCHEMBL1073052 | 0.73 | KMT2A (0.51) | HTTALDH1A1KDM4EHPGDCNR2 | |
| SCHEMBL5455218 | 0.73 | HTT (0.56) | HTTALDH1A1KDM4ELMNAHPGD | |
| SCHEMBL1752837 | 0.72 | CNR2 (0.64) | HTTALDH1A1KDM4ECNR2MAPT | |
| SCHEMBL2954119 | 0.72 | CKS1B (0.57) | ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7300932-B2 | Pyrrolo[1,2-b]pyridazine derivatives | JAPAN TOBACCO INC. (JP) | 2007-11-27 | — | — | US | disclosed |
| CN-1913899-A | Anorectic compounds | JAPAN TOBACCO INC (JP) | 2007-02-14 | — | — | CN | disclosed |
| US-20070027093-A1 | Anorectic | JAPAN TOBACCO INC. (JP) | 2007-02-01 | — | — | US | disclosed |
| EP-1653969-A4 | PYRROLO 1,2-B PYRIDAZINE DERIVATIVES | JAPAN TOBACCO INC (JP) | 2006-12-20 | — | — | EP | disclosed |
| EP-1718309-A2 | ANORECTIC COMPOUNDS | Japan Tobacco, Inc. (JP) | 2006-11-08 | — | — | EP | disclosed |
| EP-1653969-A2 | PYRROLO 1,2-B PYRIDAZINE DERIVATIVES | Japan Tabacco Inc. (JP) | 2006-05-10 | — | — | EP | disclosed |
| WO-2005072740-A2 | ANORECTIC COMPOUNDS | JAPAN TOBACCO INC. (JP) | 2005-08-11 | — | — | WO | disclosed |
| US-20050070545-A1 | For treatment or prevention of metabolic and cell proliferative diseases; modifying lipid metabolism | TULARIK INC. (US) | 2005-03-31 | — | — | US | disclosed |
| WO-2005013907-A2 | PYRROLO[1,2-B]PYRIDAZINE DERIVATIVES | JAPAN TOBACCO INC. (JP) | 2005-02-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050070545-A1 | For treatment or prevention of metabolic and cell proliferative diseases; modifying lipid metabolism | PC, ACACB, ACAT1 | HTT 894/4885ALDH1A1 978/4885KDM4E 2907/4885 |
| US-20070027093-A1 | Anorectic | DGAT1, DGAT2, GPR119 | HTT 1859/4885ALDH1A1 303/4885KDM4E 2110/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.